Abstract
Three new dammarane-type saponins, compounds 1 - 3, were isolated from the aerial parts of Gynostemma pentaphyllum. Their structures were determined using NMR analysis and acid hydrolysis. The structure and stereochemistry of compound 1 were confirmed by X-ray crystallography.
References
-
1
Lin C C, Huang P C, Lin J M.
Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum
.
Am J Chinese Med.
2000;
28
87-96
-
2
Chen J C, Chung J G, Chen L D.
Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells.
Cytobios.
1999;
100
37-48
-
3
Ma Z R, Yang Z B.
Scavenging effects of Astragalus and Gynostemma pentaphyllum with its product on O2
- and OH.
Zhong Yao Cai.
1999;
22
303-6
-
4
Wang Q F, Chen J C, Hsieh S J, Cheng C C, Hsu S L.
Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells.
Cancer Lett.
2002;
183
169-78
-
5
Zhou Z T, Wang Y, Zhou Y M, Zhang S L.
Effect of Gynostemma penta-phyllum Mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study.
Chinese Med J Peking.
1998;
111
847-50
-
6
Kuwahara M, Kawanishi F, Komiya T, Oshio H.
Dammarane saponins from Gynostemma pentaphyllum Makino and isolation of malonylginsenosides-Rb1, -Rd, and malonylgypenoside V.
Chem Pharma Bull.
1989;
37
135-9
-
7
Takimoto T, Arihara S, Nakajima T, Okuhira M.
Studies on the constituents of Gynostemma pentaphyllum Makino II. Studies of gypenosides XV - XXI.
Yakugaku Zasshi.
1983;
103
1015-23
-
8
Liu X, Ye W C, Mo Z Y, Yu B, Zhao S X, Wu H M. et al .
Five new ocotillone-type saponins from Gynostemma pentaphyllum
.
J Nat Prod.
2004;
67
1147-51
-
9
Yoshikawa K, Mitake M, Takemoto T, Arihara S.
Studies on the constituents of Curcubitaceae plants. XVII. On the saponins constituents of Gynostemma pentaphyllum Makino (12).
Yakugaku Zasshi.
1987;
107
355-60
-
10
Yoshikawa M, Murakami T, Ueno T, Yashiro K, Hirokawa N, Murakami N et a l.
Bioactive saponins and glycosides. VIII. Notoginseng (1): new dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng (Bunk.) F. H. Chen.
Chem Pharm Bull.
1997;
45
1039-45
-
11
Yoshikawa M, Murakami T, Ueno T, Hirokawa N, Yashiro K, Murakami N et a l.
Bioactive saponins and glycosides. IX. Notoginseng (2): structures of five new dammarane-type triterpene oligoglycosides, notoginsenosides-E, -G, -H, -I, and -J, and a novel acetylenic fatty acid glycoside, notoginsenic acid β-sophoroside, from the dried root of Panax notoginseng (Bunk.) F. H. Chen.
Chem Pharm Bull.
1997;
45
1056-62
-
12
Mo Z Y, Hsiao W LW.
Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in Rat 6 fibroblast cell system.
Proc Am Assoc Cancer Res.
2002;
43
961
Dr. W. L. Wendy Hsiao
School of Chinese Medicine
Hong Kong Baptist University
Hong Kong
People’s Republic of China
Fax: +852-3411-2461
Email: bowhsiao@hkbu.edu.hk