Abstract
To assess possible herb-drug interactions, rutaecarpine (an herbal ingredient of Evodia rutaecarpa; 25 mg/kg/day, p. o.), the ethanol extract of Evodia rutaecarpa (1 g/kg/day, p. o.), and an herbal preparation of Evodia rutaecarpa (Wu-Chu-Yu-Tang; 1 g/kg/day) were individually pretreated daily for three consecutive days in rats and on the fourth day caffeine was administered (2 mg/kg, i. v.). Caffeine concentrations in blood, brain and bile were concurrently measured by microdialysis coupled to a liquid chromatographic system. Pharmacokinetic data were calculated by a non-compartmental model. The results indicate that the caffeine crosses the blood-brain barrier and goes through hepatobiliary excretion. The caffeine level was significantly decreased by the pretreatment of rutaecarpine, the extract of Evodia rutaecarpa and herbal preparation Wu-Chu-Yu-Tang. This finding should be very important whenever herb-drug interactions would be possible for a herbal remedy.
Key words
Caffeine -
Evodia rutaecarpa
- Rutaceae - microdialysis - pharmacokinetics - rutaecarpine - traditional Chinese medicine
References
-
1
Chen L, Bondoc F Y, Lee M J, Hussin A H, Thomas P E, Yang C S.
Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats.
Drug Metab Dispos.
1996;
24
529-33
-
2
Asahina Y, Kashiwaki K.
1915. Chemical constituents of the fruits of Evodia rutaecarpa
.
J Pharm Soc Jpn.
1915;
35
293
-
3
Ueng Y F, Wang J J, Lin L C, Park S S, Chen C F.
Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa
.
Life Sci.
2001;
70
207-17
-
4 Tang W, Eisenbrand G.
Evodia rutaecarpa (Juss) Benth, in Chinese Drugs of Plant Origin. Tang W, Eisenbrand, G, eds Springer-Verlag Berlin; 1992: pp 509-14
-
5
Kano Y, Zong Q, Komatsu K.
1991. Pharmacological properties of galenical preparation, XIV. Body temperature retaining effect of the Chinese traditional medicine, ”Goshuyu-to” and component crude drugs.
Chem Pharm Bull.
1991;
39
690-2
-
6
Tsai T H.
Assaying protein unbound drugs using microdialysis techniques.
J Chromatogr B.
2003;
797
161-73
-
7
Tsai T H, Chen Y F, Chen I F, Chen C F.
Measurement of unbound caffeic acid in rat blood by on-line microdialysis coupled with liquid chromatography and its application to pharmacokinetic studies.
J Chromatogr B.
1999;
729
119-25
-
8
Tsai T H.
Pharmacokinetics of pefloxacin and its interaction with cyclosporin A, a P-glycoprotein modulator, in rat blood, brain and bile, using simultaneous microdialysis.
Brit J Pharmacol.
2001;
132
1310-6
-
9
Scott D O, Lunte C E.
In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol.
Pharm Res.
1993;
10
335-42
-
10 Paxinos S, Watson C. The Rat Brain in Stereotaxic Coordinates. 1982 Academic Press Sydney;
-
11
Tsai T H, Lee C H, Yeh P H.
Effect of cyclosporine, a P-glycoprotein modulator, on the disposition and biliary excretion of camptothecin using microdialysis.
Brit J Pharmacol.
2001;
134
1245-52
-
12
Tsai T H, Liu S C, Tsai P L, Ho L K, Shum A YC, Chen C F.
Pharmacokinetics of baicalein and its interaction with P-glycoprotein inhibitor, cyclosporin A, in the rat: a microdialysis study.
Brit J Pharmacol.
2002;
137
1314-20
-
13
Tsai P L, Tsai T H.
Hepatobiliary excretion of berberine.
Drug Metab Dispos.
2004;
32
405-12
-
14
McCall A L, Millington W R, Wurtman R J.
Blood-brain barrier transport of caffeine: dose-related restriction of adenine transport.
Life Sci.
1982;
31
709-15
-
15
Holstege A, Kurz M, Weinbeck M, Gerok W.
Excretion of caffeine and its primary degradation products into bile.
J Hepatol.
1993;
17
67-73
-
16
Beach C A, Mays D C, Sterman B M, Gerber N.
Metabolism, distribution, seminal excretion and pharmacokinetics of caffeine in the rabbit.
J Pharmacol Exp Ther.
1985;
233
18-23
-
17
Lin J H, Sugiyama Y, Awazu S, Hanano M.
(1982) In vitro and in vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models.
J Pharmacokinet Biopharm.
1982;
10
637-47
-
18
Ueng Y F, Jan W C, Chen T L, Guengerich F P, Chen C F.
The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.
Drug Metab Dispos.
2002;
30
349-53
-
19
Ayalogu E O, Snelling J, Lewis D FV, Talwar S, Clifford M N, Ioannides C.
(1995) Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus.
Biochim Biophys Acta.
1995;
1272
89-94
-
20
Berthou F, Goasduff T, Dreano Y, Menez J F.
Caffeine increases its own metabolism through cytochrome P4501A induction in rats.
Life Sci.
1995;
57
541-9
-
21
Roberts E A, Furuya K N, Tang B K, Kalow W.
Caffeine biotransformation in human hepatocyte lines derived from normal liver tissue.
Biochem Biophy Res Commun.
1994;
201
559-66
-
22
Ha H R, Chen J, Krahenbuhl S, Follath F.
Biotransformation of caffeine by cDNA-expressed human cytochromes P-450.
Eur J Clin Pharmacol.
1996;
49
309-15
-
23
Ursing C, Wikner J, Brismar K, Rojdmark S.
Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2.
J Endocrinol Inv.
2003;
26
03-6
Prof. Tung-Hu Tsai, Ph. D.
National Research Institute of Chinese Medicine
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