Antihepatitis Activity (Anti-HBsAg and Anti-HBeAg) of C19 Homolignans and Six Novel C18 Dibenzocyclooctadiene Lignans from Kadsura japonica

Yao-Haur Kuo; Ming-Der Wu; Ray-Ling Huang; Li-Ming Yang Kuo; Ya-Wen Hsu; Chia-Ching Liaw; Chia-Cheng Hung; Ya-Ching Shen; Chi-Wi Ong

doi:10.1055/s-2005-871271

Planta Medica, Table of Contents

Planta Med 2005; 71(7): 646-653
DOI: 10.1055/s-2005-871271

Original Paper

Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Antihepatitis Activity (Anti-HBsAg and Anti-HBeAg) of C₁₉ Homolignans and Six Novel C₁₈ Dibenzocyclooctadiene Lignans from Kadsura japonica

Yao-Haur Kuo¹ , Ming-Der Wu¹ ^, ² , Ray-Ling Huang¹ , Li-Ming Yang Kuo¹ , Ya-Wen Hsu¹ , Chia-Ching Liaw¹ ^, ³ , Chia-Cheng Hung¹ , Ya-Ching Shen³ , Chi-Wi Ong²

¹National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, R.O.C.
²Institute of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C
³Institiute of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C.

Abstract

Bioassay-directed fractionation of the EtOAc extract of Kadsura japonica has led to the isolation of six new C₁₈ dibenzocyclooctadiene lignans, schizanrins I, J, K, L, M, N, along with four known C₁₉ homolignans, taiwanschirins A, B, C, and heteroclitin F. The elucidations of the new structures were based on spectral analysis. Bioassay evaluation against human type B hepatitis revealed that taiwanschirins A and B showed strong activity for anti-HBsAg and a medium effect for anti-HBeAg at 25 μg/mL (12.9 and 11.9 μM for taiwanschirins A and B, respectively).

Key words

Kadsura japonica - Schizandraceae - dibenzocyclooctadiene - taiwanschirin - schizanrin - anti-HBsAg - anti-HBeAg - antihepatitis activity - lignans

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Prof. Yao-Haur Kuo

National Research Institute of Chinese Medicine

Shih-Pai

Taipei 112

Taiwan

Republic of China

Phone: 886-2-28201999 ext. 7061

Fax: +886-2-28236150

Email: kuoyh@nricm.edu.tw