Antihepatitis Activity (Anti-HBsAg and Anti-HBeAg) of C₁₉ Homolignans and Six Novel C₁₈ Dibenzocyclooctadiene Lignans from Kadsura japonica

Abstract

Bioassay-directed fractionation of the EtOAc extract of Kadsura japonica has led to the isolation of six new C₁₈ dibenzocyclooctadiene lignans, schizanrins I, J, K, L, M, N, along with four known C₁₉ homolignans, taiwanschirins A, B, C, and heteroclitin F. The elucidations of the new structures were based on spectral analysis. Bioassay evaluation against human type B hepatitis revealed that taiwanschirins A and B showed strong activity for anti-HBsAg and a medium effect for anti-HBeAg at 25 μg/mL (12.9 and 11.9 μM for taiwanschirins A and B, respectively).

Key words

Kadsura japonica - Schizandraceae - dibenzocyclooctadiene - taiwanschirin - schizanrin - anti-HBsAg - anti-HBeAg - antihepatitis activity - lignans

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