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Planta Med 2005; 71(7): 680-682
DOI: 10.1055/s-2005-871276
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxicities of Xanthones and Cinnamate Esters from Hypericum hookerianum

Rujida Wilairat1 , 2 , Jiradej Manosroi2 , Aranya Manosroi2 , Anake Kijjoa1 , 3 , Maria São José Nascimento4 , Madalena Pinto5 , Artur M. S. Silva6 , Graham Eaton7 , Werner Herz8
  • 1ICBAS-Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal
  • 2Department of Pharmaceutical Science, Faculty of Pharrmacy, Chiang Mai University, Chiang Mai, Thailand
  • 3CIIMAR-Centro Interdisciplinar de Investigação Marítima e Ambiental, Universidade do Porto, Porto, Portugal
  • 4Laboratório de Microbiologia, Faculdade de Farmácia e Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto (CEQOFFUP), Universidade do Porto, Porto, Portugal
  • 5Laboratório de Química Orgânica, Faculdade de Farmácia e Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto (CEQOFFUP), Universidade do Porto, Porto, Portugal
  • 6Department de Química, Universidade de Aveiro, Aveiro, Portugal
  • 7Department of Chemistry, Leicester University, Leicester, UK
  • 8Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, USA
Further Information

Publication History

Received: September 3, 2004

Accepted: April 2, 2005

Publication Date:
18 July 2005 (online)

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Abstract

5-Hydroxy-2-methoxyxanthone (1), 2-hydroxy-3-methoxyxanthone (2), trans-kielcorin (3), 4-hydroxy-3-methoxyphenyl ferulate (4) and 3β-O-caffeoylbetulinic acid (5) were isolated from Hypericum hookerianum. Compounds 1 - 5 were tested against the growth of three human tumor cell lines, MCF-7, NCI-H460 and SF-268. Compounds 4 and 5 exhibited significant inhibitory activity effects against all three; GI50 values for 4 were 15.1 ± 1.6, 18.7 ± 2.3 and 15.9 ± 2.7 and for 5 12.2 ± 2.4, 19.6 ± 2.3 and 24.3 ± 2.5. Compound 3 was less active with GI50 values of 55.1 ± 2.3, 49.7 ± 3.0 and 40.5 ± 1.5, while 1 and 2 exhibited only weak effects. Compounds 4 and 5 were moderately effective in influencing the mitogenic response to human lymphocytes to hemoagglutinin, with IC values of 26.1 ± 3.6 and 40.8 ± 4.9, respectively.

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Prof. Werner Herz

Department of Chemistry and Biochemistry

Florida State University

Tallahassee

FL32306-4390

Fax: +1-850-644-8281

Email: jdulin@chem.fsu.edu