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Synthesis 2005(16): 2677-2682  
DOI: 10.1055/s-2005-872098
PAPER
© Georg Thieme Verlag Stuttgart · New York

Anilinosilanes/TBAF Catalyst: Mild and Powerful Agent for the Silylation of Sterically Hindered Alcohols

Akira Iida, Atsushi Horii, Tomonori Misaki, Yoo Tanabe*
Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyougo 669-1337, Japan
Fax: +81(79)5659077; e-Mail: tanabe@kwansei.ac.jp;
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Publication History

Received 4 April 2005
Publication Date:
22 July 2005 (online)

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Abstract

We developed an efficient method for the silylation of alcohols using anilinosilane with tetrabutylammonium fluoride (TBAF) catalyst, wherein TMS, TES and TBS groups were smoothly introduced into silylation-resistant hindered alcohols under mild conditions.

Key words

alcohols - silylation - anilinosilane - TBAF - catalyst