The Egogram Is a Potent, Independent Risk Factor for Hypertension in Pregnancy

ABSTRACT

To assess the association between the egogram and hypertension in pregnancy (HP), a case-control study was carried out. Seventy-one HP cases, primiparous aged 20 to 34 years, and 109 controls, were enrolled among pregnant women who visited our hospitals for obstetrical care. Data from a self-administered questionnaire containing a Self Grow-Up Egogram (SGE) were subjected to univariate and multivariate analyses with prepregnancy body mass index (BMI) and angiotensinogen (AGT) genotype. The mean ± standard error of total scores for the critical parent (CP) scale were 9.7 ± 0.5 for cases and 8.3 ± 0.3 for controls, those for the nurturing parent (NP) scale were 13.6 ± 0.4 for cases and 13.4 ± 0.3 for controls, those for the adult (A) scale were 11.3 ± 0.5 for cases and 10.9 ± 0.3 for controls, those for the free child (FC) scale were 12.3 ± 0.3 for cases and 13.8 ± 0.3 for controls, and those for the adapted child (AC) scale were 10.2 ± 0.4 for cases and 8.5 ± 0.4 for controls. A low FC scale score (FC ≤ 10) and a high AC scale score (AC > 10) were significantly associated with HP (p < 0.05; p < 0.01, respectively). In the multivariate analysis, FC ≤ 10, AC > 10, prepregnancy BMI ≥ 24, and homozygosity of the T235 allele genotype of the AGT gene were detected as the potent independent risk factors for HP. The odds ratios were 2.2, 2.8, 4.0, and 2.5, respectively. The present results suggest that a low FC score and a high AC score may be potent, independent risk factors for HP.

Egogram - personality - preeclampsia - hypertension - pregnancy

REFERENCES

• 1 Pipkin F B, Rubin P C. Pre-eclampsia-the ‘disease of theories’.  Br Med Bull. 1998;  50 381-396
• 2 National High Blood Pressure Education Program Working Group . Report on high blood pressure in pregnancy (Consensus Report).  Am J Obstet Gynecol. 1990;  163 1689-1712
• 3 Kobashi G. Gene polymorphisms and preeclampsian Japanese; Analysis for gene-environment interaction.  , [in Japanese] Acta Obstet Gynaecol Jpn. 2003;  55 817-829
• 4 Kobashi G, Shido K, Hata A et al.. Multivariate analysis of genetic and acquired factors; T235 variant of the angiotensinogen gene is a potent independent risk factor for preeclampsia.  Semin Thromb Hemost. 2001;  27 143-147
• 5 Kobashi G, Hata A, Shido K et al.. M235T variant of angiotensinogen gene and body mass index are useful markers for prevention of hypertension in pregnancy; a tree-based analysis of gene-environment interaction.  Semin Thromb Hemost. 2001;  27 501-505
• 6 Morgan T, Craven C, Lalouel J M, Ward K. Angiotensinogen Thr235 variant is associated with abnormal physiologic change of the uterine spinal arteries in first-trimester decidua.  Am J Obstet Gynecol. 1999;  180 95-102
• 7 Nisell H, Larsson G, Wager J. The relation between life stress and hypertensive complications during pregnancy.  Acta Obstet Gynecol Scand. 1989;  68 423-427
• 8 Paarlberg K M, Vingerhoets A J, Passchier J, Dekker G A, Van Geijn H P. Psychosocial factors and pregnancy outcome: a review with emphasis on methodological issues.  Psychosom Res. 1995;  39 S3-S5
• 9 Nakahara Y, Mochizuki Y, Miyamoto Y et al.. Mental state as a possible independent prognostic variable for survival in patients with advanced lung carcinoma.  Cancer. 2002;  94 3006-3015
• 10 Takajiri M, Ashihara M, Katsura T. A study of a new egogram (SGE).  , [in Japanese] Jap J Transactional Analysis. 1994;  19 45-49
• 11 Dusay J M. Egograms and the “constancy hypothesis”.  Transactional Analysis J. 1972;  2 37-41
• 12 Berne E. Transactional Analysis in Psychotherapy. New York; Grove Press 1961
• 13 Ushiroyama T, Sugimoto O. Clinical observation of personality characteristics of perimenopausal women with undefined complaints.  Asia Oceania J Obstet Gynaecol. 1993;  19 67-70