Synlett 2022(16): 2461-2464  
DOI: 10.1055/s-2005-872701
LETTER
© Georg Thieme Verlag Stuttgart · New York

Phosphomolybdic Acid Supported on Silica Gel: An Efficient, Mild and Reusable Catalyst for the Chemoselective Hydrolysis of Acetonides

J. S. Yadav*, S. Raghavendra, M. Satyanarayana, E. Balanarsaiah
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India
Fax: +91(410)7160387; e-Mail: yadavpub@iict.res.in;
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Publication History

Received 26 May 2005
Publication Date:
21 September 2005 (online)

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Abstract

Carbohydrate acetonides were chemoselectively cleaved to the corresponding diols by using environmentally benign phosphomolybdic acid (H3PMo12O40) supported on silica gel (PMA-SiO2) at ambient temperature in a short span of 5-7 minutes in acetonitrile. Acid-labile protective groups such as THP, TBS, TBDPS, MOM, OMe and PMB were found to be stable under the reaction conditions.

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