A case of necrotizing enterocolitis in a 19-year old man treated for schizophrenic
disorder, induced by a drug association involving clozapine and requiring surgical
treatment, is presented. To our knowledge only few reports have described the occurrence
of this complication with atypical antipsychotics. Evidence for linking this complication
to clozapine was reinforced by the absence of any viral or bacterial infection. The
authors present a review of similar cases, stress the potential hazards induced by
such drug combinations and discuss supposed mechanisms of this enterocolitis.
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Dr. Raphaël Gourevitch
Service Hospitalo Universitaire
Sainte-Anne Hospital
7 Rue Cabanis
75014 Paris
France
Phone: +33 1 4438 5270
Fax: +33 1 4438 5279
Email: r.gourevitch@ch-sainte-anne.fr
