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Pharmacopsychiatry 2005; 38(5): 220-221
DOI: 10.1055/s-2005-873157
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Necrotizing Enterocolitis after Antipsychotic Treatment Involving Clozapine and Review of Severe Digestive Complications

A Case ReportS. Khaldi1 , R. Gourevitch1 , M. Matmar3 , A. Llory4 , J.-P. Olié1 , L. Chauvelot-Moachon2
  • 1Hôpital Sainte-Anne, Service Hospitalo-Universitaire, Paris, France
  • 2Groupe Hospitalier Cochin Saint-Vincent-de-Paul, Service de Pharmacovigilance, Paris France
  • 3Centre Hospitalier Cochin, Service de Réanimation chirurgicale, Paris, France
  • 4Centre Hospitalier Cochin, Service de Chirurgie digestive, Paris, France
Further Information

Publication History

Received: 4.9.2004 Revised: 24.1.2005

Accepted: 18.4.2005

Publication Date:
27 September 2005 (online)

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A case of necrotizing enterocolitis in a 19-year old man treated for schizophrenic disorder, induced by a drug association involving clozapine and requiring surgical treatment, is presented. To our knowledge only few reports have described the occurrence of this complication with atypical antipsychotics. Evidence for linking this complication to clozapine was reinforced by the absence of any viral or bacterial infection. The authors present a review of similar cases, stress the potential hazards induced by such drug combinations and discuss supposed mechanisms of this enterocolitis.

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Dr. Raphaël Gourevitch

Service Hospitalo Universitaire

Sainte-Anne Hospital

7 Rue Cabanis

75014 Paris

France

Phone: +33 1 4438 5270

Fax: +33 1 4438 5279

Email: r.gourevitch@ch-sainte-anne.fr