Two New Abietane Diterpenoids from Salvia yunnanensis

Abstract

Two new abietane diterpenoids, yunnannin A (1) and danshenol C (2), were isolated from Salvia yunnanensis together with ten known diterpenoids, danshenol A (3), przewalskin (4), tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8,11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds 1 - 3 were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound 3 showed inhibited growth of K562 (IC₅₀ = 0.53 μg/mL), T-24 (IC₅₀ = 7.94 μg/mL), QGY (IC₅₀ = 4.65 μg/mL) and Me180 (IC₅₀ = 6.89 μg/mL) cell lines while compound 2 was inactive. Compound 1 showed moderate inhibitory activity on QGY (IC₅₀ = 16.75 μg/mL) and Me180 (IC₅₀ = 5.84 μg/mL) cells.

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