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Aktuelle Neurologie 2006; 33(9): 509-524
DOI: 10.1055/s-2005-915406
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© Georg Thieme Verlag KG Stuttgart · New York

Vaskuläre Demenz und Morbus Alzheimer: Abgrenzung und Überlappung

Vascular Dementia and Alzheimer Disease: Overlap and DifferentiationK.  Schmidtke
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Publication Date:
02 November 2006 (online)

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Weiterbildungsziele

In diesem Beitrag sollen folgende Weiterbildungsziele vermittelt werden:

Unterschiedliche Formen vaskulär bedingter Demenzsyndrome Klinische, neuropsychologische und strukturelle Abgrenzung vaskulärer Demenzen gegenüber der Alzheimer-Demenz Diagnose der degenerativ/vaskulären Mischdemenz Befunde und Hypothesen zur vaskulären Komponente der Alzheimer-Demenz

Literatur

  • 1 Roman G C, Tatemichi T K, Erkinjuntti T. et al . Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop.  Neurology. 1993;  43 250-260
    CrossrefPubMedSearch in Google Scholar
  • 2 Barker W E, Luis C A, Kashuba A. et al . Relative frequencies of Alzheimer's disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank.  Alzheimer Disease and Associated Disorders. 2002;  16 203-212
    CrossrefPubMedSearch in Google Scholar
  • 3 Lobo A, Launer L J, Fratiglioni L. et al . Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts.  Neurology. 2000;  54 (suppl 5) S4-S9
    CrossrefPubMedSearch in Google Scholar
  • 4 Erkinjuntti T, Gauthier S. Vascular Cognitive Impairment. London; Martin Dunitz 2002
    Search in Google Scholar
  • 5 Haberl R L, Schreiber A K. Vaskuläre Demenzen. In: Wallesch CW, Förstl H (Hrsg) Demenzen. Stuttgart; Thieme 2005: 221-229
    Search in Google Scholar
  • 6 Schmidtke K. Demenzen. Diagnostik und Behandlung in der Facharztpraxis und Gedächtnissprechstunde. Kapitel 8: Demenz bei vaskulären Schädigungen. Stuttgart; Kohlhammer 2006: 208-232
    Search in Google Scholar
  • 7 O'Brian J, Reisberg B, Erkinjuntti T. IPA Expert Consensus Conference „Vascular Burden of the Brain: New Therapeutic Directions”.  International Psychogeriatrics. 2003;  15, Suppl 1
    PubMedSearch in Google Scholar
  • 8 Hamann G, Böhm M, Busse O. et al .Vaskuläre Demenzen. In: Diener HC, Hacke W (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie. 3. Auflage. Stuttgart; Thieme 2005: 130-141
    Search in Google Scholar
  • 9 White L, Petrovitch H, Hardman J. et al . Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants.  Annals of the New York Academy of Science. 2002;  977 9-23
    PubMedSearch in Google Scholar
  • 10 Kövari E, Gold G, Herrmann F R. et al . Cortical microinfarcts and demyelination significantly affect cognition in brain aging.  Stroke. 2004;  35 410-414
    CrossrefPubMedSearch in Google Scholar
  • 11 Moretti R, Torre P, Antonello R. et al . Neuropsychological evaluation of late-onset post-radiotherapy encephalopathy: a comparison with vascular dementia.  Journal of the Neurological Sciences. 2005;  229 - 230 195-200
    CrossrefPubMedSearch in Google Scholar
  • 12 Baezner H, Hennerici M. From trepidant abasia to motor networt failure - gait disorders as a consequence of subcorctical vascular encephalopathy (SVE). Review of historical and contemporary concepts.  Journal of the Neurological Sciences. 2005;  229 - 230 81-88
    CrossrefPubMedSearch in Google Scholar
  • 13 Schmidt R, Schmidt H, Lapeller P, Fazekas F. Slow progression of white-matter changes.  International Psychogeriatrics. 2003;  15 (Suppl 1) 173-176
    CrossrefPubMedSearch in Google Scholar
  • 14 Schmidtke K, Hüll M. Cerebral Small Vessel Disease: how does it progress?.  Journal of the Neurological Sciences. 2005;  229 - 230 13-20
    CrossrefPubMedSearch in Google Scholar
  • 15 Reed B R, Eberling J L, Mungas D. et al . Effects of white matter lesions and lacunes on cortical function.  Arch Neurol. 2002;  61 1545-1550
    PubMedSearch in Google Scholar
  • 16 Schmidtke K, Hüll M. Neuropsychological differentiation of Small Vessel Disease, Alzheimer's Disease and Mixed Dementia.  Journal of the Neurological Sciences. 2002;  9 419-429
    PubMedSearch in Google Scholar
  • 17 Satzger W, Hampel H, Padberg F. et al . Zur praktischen Anwendung der CERAD-Testbatterie als neuropsychologisches Defizitscreening.  Nervenarzt. 2001;  72 196-203
    CrossrefPubMedSearch in Google Scholar
  • 18 Shulman K I. Clock-drawing: is it the ideal cognitive screening test?.  Int J Geriatr Psychiatry. 2000;  15 548-561
    CrossrefPubMedSearch in Google Scholar
  • 19 Oswald W D, Fleischmann U M. Psychometrics in aging and dementia: advances in geropsychological assessments.  Arch Gerontol Geriatr. 1985;  4 299-309
    CrossrefPubMedSearch in Google Scholar
  • 20 Pantoni L, Simoni M. Pathophysiology of cerebral small vessels in vascular cognitive impairment.  International Psychogeriatrics. 2003;  15, Suppl 1 59-65
    PubMedSearch in Google Scholar
  • 21 Moody D M, Bell M A, Challa V R. The corpus callosum, a unique white-matter tract: anatomic features that may explain sparing in Binswanger disease and resistance to flow of fluid masses.  Am J Neuroradiol. 1988;  9 1051-1059
    PubMedSearch in Google Scholar
  • 22 Straaten E C van, Scheltens P, Knol D L. et al . Operational definitions for the NINDS-AIREN criteria for vascular dementia. An interobserver study.  Stroke. 2003;  34 1907-1912
    CrossrefPubMedSearch in Google Scholar
  • 23 Jobst K A, Barnetson L P, Shepstone B J. Accurate prediction of histologically confirmed Alzheimer's disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and Apo E4 in medial temporal lobe dementias. Oxford Project to Investigate Memory and Aging.  Int Psychogeriatr. 1998;  10 271-302
    CrossrefPubMedSearch in Google Scholar
  • 24 Dougall N J, Bruggink S, Ebmeier K P. Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia.  Am J Geriatr Psychiatry. 2004;  12 554-570
    Search in Google Scholar
  • 25 Wolf H, Ecke G M, Bettin S. et al . Do white matter changes contribute to the subsequent development of dementia in patients with mild cognitive impairment? A longitudinal study.  Int J Geriatr Psychiatry. 2000;  15 803-812
    PubMedSearch in Google Scholar
  • 26 Feigin V, Ratnasabapathy Y, Anderson C. Does blood pressure lowering treatment prevent dementia or cognitive decline in patients with cardiovascular and cerebrovascular disease?.  Journal of the Neurological Sciences. 2005;  229 - 230 151-155
    CrossrefPubMedSearch in Google Scholar
  • 27 Benson D F, Cummings J L. Angular gyrus syndrome imitating Alzheimer's Disease.  Archives of Neurology. 1982;  39 616-620
    PubMedSearch in Google Scholar
  • 28 Torre J C de la. Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics.  Lancet Neurology. 2004;  3 184-190
    CrossrefPubMedSearch in Google Scholar
  • 29 Hentschel F, Supprian T, Frölich L. Alzheimer-Demenz versus vaskuläre Demenz - Dichotomie oder Interaktion?.  Fortschritte der Neurologie Psychiatrie. 2005;  73 317-326
    PubMedSearch in Google Scholar
  • 30 Jellinger K, Attems J. Incidence of cerebrovascular lesions in Alzheimer's disease: a postmortem study.  Acta Neuropathologica. 2003;  105 14-17
    PubMedSearch in Google Scholar
  • 31 Honig L S, Tang M X, Albert S. et al . Stroke and the risk of Alzheimer disease.  Archives of Neurology. 2003;  60 1707-1712
    CrossrefPubMedSearch in Google Scholar
  • 32 Snowdon D A, Grenier L H, Mortimer J A. et al . Brain infarction and the clinical expression of Alzheimer disease: The Nun Study.  JAMA. 1997;  227 813-817
    PubMedSearch in Google Scholar
  • 33 DeCarli C. Vascular factors in dementia: an overview.  Journal of the Neurological Sciences. 2004;  226 19-23
    CrossrefPubMedSearch in Google Scholar
  • 34 Sjögren M, Blennow K. The link between cholesterol and Alzheimer's disease.  World Journal of Biological Psychiatry. 2005;  6 85-97
    PubMedSearch in Google Scholar
  • 35 Luchsinger J A, Mayeux R. Cardiovascular risk factors and Alzheimer's disease.  Current Atherosclerosis Reports. 2004;  6 261-266
    PubMedSearch in Google Scholar
  • 36 Seshadri S, Beiser A, Selhub J. et al . Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.  New England Journal of Medicine. 2002;  346 476-483
    CrossrefPubMedSearch in Google Scholar
  • 37 Skoog I, Lernfeldt B, Landahl S. et al . 15-year longitudinal study of blood pressure and dementia.  Lancet. 1996;  347 1141-1145
    CrossrefPubMedSearch in Google Scholar
  • 38 Iadecola C, Gorelick P B. Converging pathogenetic mechanisms in vascular and neurodegenerative dementia.  Stroke. 2003;  34 335-337
    CrossrefPubMedSearch in Google Scholar
  • 39 Schmidt R, Schmidt H, Kapeller P. et al . The natural course of MRI white matter hyperintensities.  Journal of the Neurological Sciences. 2002;  203 - 204 253-257
    CrossrefPubMedSearch in Google Scholar
  • 40 Sabri O, Hellwig D, Schreckenberger M. et al . One-year follow-up of neuropsychology, MRI, rCBF and glucose metabolism (rMRGlu) in cerebral microangiopathy.  Nuklearmedizin. 2000;  39 43-49
    PubMedSearch in Google Scholar
  • 41 Groot J C De, Leeuw F E De, Oudkerk M. et al . Periventricular cerebral white matter lesions predict rate of cognitive decline.  Ann Neurol. 2002;  52 335-341
    CrossrefPubMedSearch in Google Scholar
  • 42 Bracco L, Campani D, Baratti E. et al . Relation between MRI features and dementia in cerebrovascular disease patients with leukoaraiosis: a longitudinal study.  J Neurol Sci. 1993;  120 131-136
    CrossrefPubMedSearch in Google Scholar
  • 43 Tian J, Shi J, Mann D M. Cerebral amyloid angiopathy and dementia.  Panminerva Medica. 2004;  46 253-264
    PubMedSearch in Google Scholar
  • 44 Jellinger K, Attems J. Prevalence and pathogenetic role of cerebrovascular lesions in Alzheimer disease.  Journal of the Neurological Sciences. 2005;  229 - 230 37-41
    CrossrefPubMedSearch in Google Scholar
  • 45 Nicoll J AR, Yamada M, Frackowiak J. et al . Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease.  Neurobiology of Aging. 2004;  25 589-597
    CrossrefPubMedSearch in Google Scholar
  • 46 Garde E, Mortensen E L, Krabbe K. et al . Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study.  Lancet. 2000;  356 628-634
    CrossrefPubMedSearch in Google Scholar
  • 47 Sabri O, Ringelstein E B, Hellwig D. et al . Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy.  Stroke. 1999;  30 556-566
    PubMedSearch in Google Scholar

Prof. Dr. K. Schmidtke

ZGGF

Lehener Straße 88

79106 Freiburg

Email: klaus.schmidtke@uniklinik-freiburg.de