Abstract
A liquid-phase traceless route to 3,5-disubstituted-1,2,4-triazoles has been developed, which allows for the incorporation of two elements of diversity. The heterocycle was constructed upon PEG6000 (soluble polymer) modified by 4-hydroxy-2-methoxybenzaldehyde, from which a traceless cleavage could be realized with TFA-CH2 Cl2 . This method provided a library of 3,5-disubstituted-1,2,4-triazoles with high yields and purity.
Key words
soluble polymer - 1,2,4-triazoles - Lawesson’s reagent - cyclization reaction - traceless cleavage
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