Abstract
A new methodology for the synthesis of N -arylpiperazines was developed using a poly(ethylene glycol)-derived solid support. The reactions proceeded in up to 60% overall yield over four steps. The scope and limitations of the method are discussed, as well as the utility of 13 C gel-phase NMR spectroscopy for reaction monitoring.
Key words
N -arylpiperazines - solid-phase synthesis - heterocycles - cleavage -
13 C gel-phase NMR spectroscopy
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