Synlett, Table of Contents ACCOUNT © Georg Thieme Verlag Stuttgart · New York The Ever-Challenging Quassinoids Claude Spino*Département de Chimie, Université de Sherbrooke, 2500 Boul. Université, Sherbrooke, QC, J1K 2R1, CanadaFax: +1(819)8218017; e-Mail: Claude.Spino@USherbrooke.ca; Recommend Article Abstract Buy Article All articles of this category Abstract The evolution of a synthetic approach to the challenging targets quassinoids is described. 1 Introduction 2 The Diels-Alder Reaction as a Key Feature 2.1 Intermolecular Diels-Alder 2.2 Intramolecular Diels-Alder 2.3 Unsuccessful Diels-Alder Cycloadditions 3 The Diene-Transmissive Approach to Quassinoids 3.1 Without the C10 Methyl Group 3.2 With the C10 Methyl Group 4 A Successful Sequence 5 Conclusion and Outlook Key words quassinoids - Simaroubacea - diene-transmissive Diels-Alder cycloaddition - vinylallenes - SN2′ displacement Full Text References References For reviews on the isolation and biological activities of quassinoids, see: 1a Guo Z. Vangapandu S. Sindelar RW. Walker LA. Sindelar RD. Curr. Med. Chem. 2005, 12: 173 1b Okano M. Fukamiya N. Lee KH. Stud. Nat. Prod. Chem. 1990, 7: 369 1c Polonsky J. 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