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Thorac Cardiovasc Surg 2006; 54(8): 537-543
DOI: 10.1055/s-2006-924479
Original Thoracic

© Georg Thieme Verlag KG Stuttgart · New York

Tumor Volume is a Better Prognostic Factor than Greatest Tumor Diameter in Stage Ia Non-small Cell Lung Cancer

C.-H. Tsai1 , C.-M. Lin2 , C.-C. Hsieh2 , W.-H. Hsu2 , H.-W. Wang3 , L.-S. Wang3
  • 1Department of Surgery, Ilan Hospital, I‐lan City, Taiwan - Republic of China
  • 2Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei City, Taiwan - Republic of China
  • 3Division of Thoracic Surgery, Department of Surgery, Taipei Far Eastern Memorial Hospital, Pan-Chiao City, Taipei County, Taiwan- Republic of China
Further Information

Publication History

Received February 26, 2006

Publication Date:
06 December 2006 (online)

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Abstract

Objective: The objective was to determine whether tumor volume, calculated by multiplying 3-dimensional diameters recorded from surgical specimens, could represent tumor size more precisely than the currently used greatest tumor diameter (T status) as a prognostic factor in early-stage non-small cell lung cancer (NSCLC). Methods: From 1991 to 2001, a total of 236 stage Ia NSCLC patients underwent curative resection in our institution. Their clinicopathological factors were retrospectively reviewed. The cases were grouped according to stereographic tumor size. Group 1 included tumor volumes less than 0.5236 (13 × π/6) cm3, Group 2 included tumor volumes between 0.5236 - 4.1888 (23 × π/6) cm3, while Group 3 included tumor volumes between 4.188 - 14.1372 (33 × π/6) cm3. Overall survival and disease-free interval analyses were performed with the Kaplan-Meier method and multivariable Cox's proportional hazard model. Tumor volume and other clinico-pathological factors were included for analysis. Results: Median follow-up was 55.5 months. The overall 5- and 10-year survival rates were 78 % and 71 %, and the 5- and 10-year disease-free intervals were 68 % and 64 %, respectively. The overall survival (p = 0.0075) and disease-free interval (p = 0.0025) showed significant differences between tumor volume groups. Smoking history, presence of symptoms and the number of resected lymph nodes were also significantly related to overall survival and disease-free interval. Conclusion: The products of 3-D diameters (tumor volume) more precisely evaluated tumor size as well as survival of patients with stage Ia NSCLC.

Key words

Thoracic surgery - non-small cell lung cancer - tumor volume - tumor size

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MD, Professor of Surgery Liang-Shun Wang

Division of Thoracic Surgery
Department of Surgery
Taipei Far Eastern Memorial Hospital
Institution of Emergency and Critical Care Medicine, National Yang-Ming University

No 21, Sec. 2, Nan-Ya South Road, Pan-Chiao City

Taipei County

Taiwan, R.O.C.

Phone: + 88 62 28 75 75 46

Fax: + 88 62 28 73 14 88

Email: lswang@vghtpe.gov.tw