Synthesis and Applications of β-Aminoethanesulfonyl Azides

Abstract

A very efficient method for the synthesis of β-amino­ethanesulfonyl azides is descibed. These aliphatic sulfonyl azides are accessible starting from a variety of protected amino acids, including those having functionalized side chains. Furthermore, these sulfonyl azides can be coupled to thio acids, and can be substituted with different aliphatic amines.

Key words

sulfonyl azide - sulfonyl chloride - amino acid - sulfon­amides

References

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17

In the NMR spectra, also broad, low-intensity signals were observed, presumably due to the presence of the minor Fmoc rotamer.