Synthesis 2006(5): 807-812  
DOI: 10.1055/s-2006-926339
PAPER
© Georg Thieme Verlag Stuttgart · New York

Rapid Microwave-Assisted Syntheses of Derivatives of HIV-1 Entry Inhibitors

Chris McFarlanda, David A. Vicic*a, Asim Kumar Debnath*b
a Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA
e-Mail: dvicic@uark.edu;
b Laboratory of Molecular Modeling and Drug Design of the Lindsley F. Kimball Research Institute of the New York Blood Center, 310 E. 67th St., New York, NY 10021, USA
Further Information

Publication History

Received 20 September 2005
Publication Date:
07 February 2006 (online)

Abstract

The direct amidation of esters with 4-amino-2,2,6,6-tetramethylpiperidine was achieved by computer-controlled microwave irradiation in toluene. The microwave protocol allowed the new amides to be prepared in three hours rather than the three days required by traditional thermal methods.

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Crystallographic data (excluding structure factors) for compound 2 have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 286628. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax:+44 (1223)336033 or e-mail: deposit@ccdc.cam.ac.uk].