Pharmacopsychiatry 2006; 39: 21-25
DOI: 10.1055/s-2006-931485
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Aripiprazole: Pharmacodynamics of a Dopamine Partial Agonist for the Treatment of Schizophrenia

G. Gründer1 , M. Kungel2 , M. Ebrecht2 , T. Göröcs2 , S. Modell2
  • 1Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Aachen, RWTH Aachen, Germany
  • 2Bristol-Myers Squibb, Medizin Neuroscience, Germany
Further Information

Publication History

Publication Date:
01 March 2006 (online)

Aripiprazole is the first approved atypical antipsychotic with a mechanism of action that exerts a partial agonism with high affinity at Dopamin D2- and Serotonin-5-HT1A-receptors as well as an antagonism at Serotonin-5-HT2 A-receptors. Aripiprazole provides good clinical effectiveness and a favorable profile of safety and tolerability. The special pharmacodynamics of aripiprazole are described herein.

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Prof. Dr. med. Gerhard Gründer

Klinik für Psychiatrie und Psychotherapie

Universitätsklinikum Aachen

RWTH Aachen

Pauwelsstr. 30

D-52074 Aachen

Germany

Phone: 0241-8088415

Fax: 0241-803388415

Email: ggruender@ukaachen.de