A Mild and Efficient Desilylation of O-tert-Butyldimethylsilyl Ethers Mediated by Chlorotrimethylsilane and Potassium Fluoride Dihydrate in Acetonitrile

Yu Peng; Wei-Dong Z. Li

doi:10.1055/s-2006-932474

LETTER

A Mild and Efficient Desilylation of O-tert-Butyldimethylsilyl Ethers Mediated by Chlorotrimethylsilane and Potassium Fluoride Dihydrate in Acetonitrile

Yu Peng, Wei-Dong Z. Li*
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
Fax: +86(931)8912539; e-Mail: liwd@lzu.edu.cn; e-Mail: isoc@lzu.edu.cn;

Abstract

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Abstract

Desilylation of O-tert-butyldimethylsilyl ethers was achieved by a reagent system consisting of chlorotrimethylsilane and potassium fluoride dihydrate in acetonitrile. This alternative desilylation procedure is chemoselective, generally effective and operationally simple, and should find practical applications in organic synthesis.

Key words

desilylation - potassium fluoride - chlorotrimethylsilane - O-tert-butyldimethylsilyl ether

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References

References and Notes

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