Abstract
Enantioselective Ir-catalyzed allylic alkylations with nitroalkanes and ethyl nitroacetate as nucleophiles are reported. Up to 99% ee was achieved using catalysts prepared by in situ activation of mixtures of phosphorus amidites and [Ir(COD)Cl]2. The method was applied to a synthesis of the antidepressant (1S,2R)-trans-2-phenylcyclopentanamine.
Key words
allylic substitution - iridium - catalysis - nitroalkanes - ring-closing metathesis
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General Procedure for Allylic Alkylation
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