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Planta Med 2006; 72(8): 715-720
DOI: 10.1055/s-2006-941507
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Anti-arthritic activity of a lipophilic woad (Isatis tinctoria) extract

María-Carmen Recio1 , Miguel Cerdá-Nicolás2 , Matthias Hamburger3 , José-Luis Ríos1
  • 1Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Spain
  • 2Department of Pathology, Faculty of Medicine, University of Valencia, Spain
  • 3Institute of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Switzerland
Further Information

Publication History

Received: 23.12.2005

Accepted: 20.4.2006

Publication Date:
31 May 2006 (online)

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Abstract

A dichloromethane extract of Isatis tinctoria was tested in the adjuvant-induced arthritis model in rats. The extract (150 mg/kg p. o.) leads to a significant reduction of paw oedema. Radiographic, histological and clinical assessment confirmed reduced damage of cartilage and signs of inflammatory response in comparison to untreated control. No significant differences were observed in the tissular levels of cyclooxygenases1 and -2, and of inducible nitric oxide synthase in Isatis treated and untreated animals. High dose treatment with Isatis extract for two weeks did not result in macroscopic lesions of the gastric mucosa.

Key words

Isatis tinctoria - Brassicaceae - adjuvant induced arthritis - inflammation - immunohistochemistry - X ray radiography - cyclooxygenase-2 - nitric oxide synthase

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Prof. José-Luis Ríos

Department of Pharmacology

Faculty of Pharmacy

University of Valencia

Av. Vicent Andrés Estellés

s/n. 46100 Burjassot

Valencia

Spain

Phone: +34963544973

Fax: +34963544973

Email: riosjl@uv.es

    www.thieme-connect.de/ejournals/toc/plantamedica