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Synlett 2006(9): 1323-1326
DOI: 10.1055/s-2006-941575
DOI: 10.1055/s-2006-941575
LETTER
© Georg Thieme Verlag Stuttgart · New York
Enantioselective Formal Synthesis of Brefeldin A and Analogues via Anionic Cyclization of an Alkenyl Epoxide
Further Information
Publication History
Received
24 February 2006
Publication Date:
22 May 2006 (online)
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Abstract
Cyclopentene derivatives suitable as intermediates for syntheses of brefeldin A and analogues 6,7-dehydrobrefeldin C and norbrefeldin A were prepared by epoxynitrile cyclization of alkenyl epoxides.
Key words
cyclizations - antitumor agents - natural products - diastereoselectivity - stereoselective synthesis