Synlett 2006(9): 1323-1326  
DOI: 10.1055/s-2006-941575
LETTER
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Formal Synthesis of Brefeldin A and Analogues via Anionic Cyclization of an Alkenyl Epoxide

Tina Hübscher, Günter Helmchen*
Organisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany
Fax: +49(6221)544205; e-Mail: G.Helmchen@oci.uni-heidelberg.de;
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Publication History

Received 24 February 2006
Publication Date:
22 May 2006 (online)

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Abstract

Cyclopentene derivatives suitable as intermediates for syntheses of brefeldin A and analogues 6,7-dehydrobrefeldin C and norbrefeldin A were prepared by epoxynitrile cyclization of alkenyl epoxides.

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