Practical and Efficient Palladium-Promoted Synthesis of Indole Systems Containing Medium- and Large-Ring-Fused Heterocycles

Abstract

The synthesis of indolo-benzazepine, indolo-benzazocine and indolo-benzazonine derivatives using a palladium-catalyzed coupling reaction is described. The polycyclic systems were obtained in a few steps directly from commercially available materials. The coupling of substrates containing aryl bromides was improved by microwave irradiation.

Key words

palladium catalyst - fused-ring systems - indoles - lactams - intramolecular cyclization

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