Synthesis, Table of Contents PAPER © Georg Thieme Verlag Stuttgart · New York Efficient Entry to Amino Sugars and Derivatives via Asymmetric Organocatalytic Mannich Reactions Dieter Enders*, Christoph Grondal, Marianna VrettouInstitut für Organische Chemie, RWTH Aachen, Landoltweg 1, 52074 Aachen, GermanyFax: +49(241)8092127; e-Mail: enders@rwth-aachen.de; Recommend Article Abstract Buy Article All articles of this category Abstract An efficient biomimetic C3+Cn entry to amino sugars and derivatives via a direct asymmetric organocatalytic Mannich methodology employing 2,2-dimethyl-1,3-dioxan-5-one as a dihydroxyacetone phosphate equivalent and N-PMP or N-Boc protected imines has been developed. The Mannich bases were obtained in high diastereo- and enantiomeric excesses (78% to >99% de, 81-98% ee) and were further elaborated using diastereoselective reduction protocols, as well as via diastereoselective direct reductive amination reactions. 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