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Planta Med 2006; 72(14): 1279-1284
DOI: 10.1055/s-2006-947257
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

The Inhibitory Effect of Triterpenoid Glycosides Originating from Sanguisorba officinalis on Tissue Factor Activity and the Production of TNF-α

Jae Youl Cho1 , 2 , Eun Sook Yoo2 , 3 , Bae Cheon Cha2 , 4 , Hwa-Jin Park5 , Man Hee Rhee6 , Yong Nam Han7
  • 1School of Biotechnology and Bioengineering, Kangwon National University, Chuncheon, South Korea
  • 2Institute of Bioscience, Daewoong Pharm. Co., Yongin, South Korea
  • 3Department of Pharmacology, College of Medicine, Cheju National University, Jeju, South Korea
  • 4Department of Bioindustry and Technology, Sangji University, Wonju, South Korea
  • 5Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University, Kimhae, South Korea
  • 6College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea
  • 7Natural Products Research Institute, Seoul National University, Seoul, South Korea
Further Information

Publication History

Received: February 6, 2006

Accepted: August 8, 2006

Publication Date:
04 October 2006 (online)

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Abstract

We examined the inhibitory effects of novel triterpene glycoside compounds [ziyu-glycoside II (ZY-II) and its methyl ester (ZYM-201)], which originated from the roots of Sanguisorba officinalis L. (Rosaceae), on tissue factor (TF) activity and tumor necrosis factor (TNF)-α production. In in vitro TF activity tests, ZY-II but not ZYM-201 strongly blocked lung TF activity with an IC50 value of 0.46 μM. By contrast, only ZYM-201 dose-dependently inhibited in vivo TF activity with an ED50 value of 1.7 mg/kg, when orally administered. Furthermore, ZYM-201 diminished both in vitro and in vivo TNF-α production with IC50 or ED50 values of 69.4 μM and 87.4 mg/kg, respectively. Therefore, these results suggest either that ZYM-201 may be developed as a potent inhibitor of both TF- and TNF-α-mediated diseases such as atherosclerosis and septic shock, or it may be a lead compound to be derivatized for further improvement of its curative efficacy.

Key words

Sanguisorba officinalis L. - Rosaceae - ziyu-glycosides - ZYM-201 - tissue factor - TNF-α

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Jae Youl Cho, PhD

School of Biotechnology and Bioengineering

Kangwon National University

192-1 Hyja-2-dong

Chuncheon

Kangwon-do 200-701

South Korea

Fax: +82-33-253-6560

Email: jaecho@kangwon.ac.kr

    www.thieme-connect.de/ejournals/toc/plantamedica