Literatur
-
1
Akira S, Takeda K, Kaisho T.
Toll-like receptors: critical proteins linking innate and acquired immunity.
Nat Immunol.
2001;
2
675-680
-
2
Apparailly F, Bouquet C, Millet V. et al .
Adenovirus-mediated gene transfer of urokinase plasminogen inhibitor inhibits angiogenesis in experimental arthritis.
Gene Ther.
2002;
9
192-200
-
3
Ballara S, Taylor P C, Reusch P. et al .
Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis.
Arthritis Rheum.
2001;
44
2055-2064
-
4
Blander J M, Medzhitov R.
Toll-dependent selection of microbial antigens for presentation by dendritic cells.
Nature.
2006;
440
808-812
-
5
Brentano F, Schorr O, Gay R E, Gay S, Kyburz D.
RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3.
Arthritis Rheum.
2005;
52
2656-2665
-
6
D’Acquisto F, Iuvone T, Rombola L, Sautebin L, Di Rosa M, Carnuccio R.
Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages.
FEBS Lett.
1997;
418
175-178
-
7
Demasi M, Cleland L G, Cook-Johnson R J, James M J.
Effects of hypoxia on the expression and activity of cyclooxygenase 2 in fibroblast-like synoviocytes: interactions with monocyte-derived soluble mediators.
Arthritis Rheum.
2004;
50
2441-2449
-
8
Distler J H, Jungel A, Huber L C. et al .
The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles.
Proc Natl Acad Sci U S A.
2005;
102
2892-2897
-
9
Distler J H, Wenger R H, Gassmann M. et al .
Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis.
Arthritis Rheum.
2004;
50
10-23
-
10
Edwards J C, Szczepanski L, Szechinski J. et al .
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.
N Engl J Med.
2004;
350
2572-2581
-
11
Fahmi H.
mPGES-1 as a novel target for arthritis.
Curr Opin Rheumatol.
2004;
16
623-627
-
12
Fassbender H G, Simmling-Annefeld M.
The potential aggressiveness of synovial tissue in rheumatoid arthritis.
J Pathol.
1983;
139
399-406
-
13
Feldmann M, Maini R N.
The role of cytokines in the pathogenesis of rheumatoid arthritis.
Rheumatology (Oxford).
1999;
(Suppl 2)
38
3-7
-
14
Firestein G S, Echeverri F, Yeo M, Zvaifler N J, Green D R.
Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium.
Proc Natl Acad Sci U S A.
1997;
94
10895-10900
-
15
Franz J K, Pap T, Hummel K M. et al .
Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis.
Arthritis Rheum.
2000;
43
599-607
-
16
Genovese M C, Bathon J M, Martin R W. et al .
Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes.
Arthritis Rheum.
2002;
46
1443-1450
-
17
Georganas C, Liu H, Perlman H, Hoffmann A, Thimmapaya B, Pope R M.
Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-kappa B but not C/EBP beta or c-Jun.
J Immunol.
2000;
165
7199-7206
-
18
Giannelli G, Erriquez R, Iannone F, Marinosci F, Lapadula G, Antonaci S.
MMP-2, MMP-9, TIMP-1 and TIMP-2 levels in patients with rheumatoid arthritis and psoriatic arthritis.
Clin Exp Rheumatol.
2004;
22
335-338
-
19
Giatromanolaki A, Sivridis E, Maltezos E. et al .
Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis.
Arthritis Res Ther.
2003;
5
R193-201
-
20
Hitchon C, Wong K, Ma G, Reed J, Lyttle D, El-Gabalawy H.
Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts.
Arthritis Rheum.
2002;
46
2587-2597
-
21
Keyszer G M, Heer A H, Kriegsmann J. et al .
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Arthritis Rheum.
1995;
38
976-984
-
22
Kinne R W, Boehm S, Iftner T. et al .
Synovial fibroblast-like cells strongly express jun-B and C-fos proto-oncogenes in rheumatoid- and osteoarthritis.
Scand J Rheumatol Suppl.
1995;
101
121-125
-
23
Konttinen Y T, Ainola M, Valleala H. et al .
Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis.
Ann Rheum Dis.
1999;
58
691-697
-
24
Kremer J M, Westhovens R, Leon M. et al .
Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig.
N Engl J Med.
2003;
349
1907-1915
-
25
Kuchen S, Seemayer C A, Rethage J. et al .
The L1 retroelement-related p40 protein induces p38delta MAP kinase.
Autoimmunity.
2004;
37
57-65
-
26
Kullmann F, Judex M, Neudecker I. et al .
Analysis of the p53 tumor suppressor gene in rheumatoid arthritis synovial fibroblasts.
Arthritis Rheum.
1999;
42
1594-1600
-
27
Kurowska-Stolarska M, Distler J H, Pap T. et al .
The inhibitor of differentiation-2 (Id-2) induced by hypoxia promotes bone degradation in rheumatoid arthritis (RA).
Arthritis Rheum.
2004;
50
S655
-
28
Maini R, St C lair EW, Breedveld F. et al. ATTRACT Study Group .
Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial.
Lancet.
1999;
354
1932-1939
-
29
Majumdar M, Tarui T, Shi B, Akakura N, Ruf W, Takada Y.
Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1).
J Biol Chem.
2004;
279
37528-37534
-
30
Miagkov A V, Kovalenko D V, Brown C E. et al .
NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint.
Proc Natl Acad Sci U S A.
1998;
95
13859-13864
-
31
Moreland L W, Pratt P W, Mayes M D. et al .
Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate.
Arthritis Rheum.
1995;
38
1581-1588
-
32
Müller-Ladner U, Gay R E, Gay S.
Retroviral sequences in rheumatoid arthritis synovium.
Int Rev Immunol.
1998;
17
273-290
-
33
Müller-Ladner U, Kriegsmann J, Franklin B N. et al .
Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice.
Am J Pathol.
1996;
149
1607-1615
-
34
Neidhart M, Rethage J, Kuchen S. et al .
Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression.
Arthritis Rheum.
2000;
43
2634-2647
-
35
Neidhart M, Wehrli R, Bruhlmann P, Michel B A, Gay R E, Gay S.
Synovial fluid CD146 (MUC18), a marker for synovial membrane angiogenesis in rheumatoid arthritis.
Arthritis Rheum.
1999;
42
622-630
-
36
Ohashi K, Burkart V, Flohe S, Kolb H.
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.
J Immunol.
2000;
164
558-561
-
37
Ospelt C, Kuenzler P, Neidhart M. et al .
p38delta induces MMP-3 expression in activated rheumatoid arthritis synovial fibroblasts.
Arthritis Rheum.
2004;
50
S155
-
38
Pages G, Pouyssegur J.
Transcriptional regulation of the Vascular Endothelial Growth Factor gene - a concert of activating factors.
Cardiovasc Res.
2005;
65
564-573
-
39
Pap T, Aupperle K R, Gay S, Firestein G S, Gay R E.
Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion.
Arthritis Rheum.
2001;
44
676-681
-
40
Pap T, Franz J K, Hummel K M, Jeisy E, Gay R, Gay S.
Activation of synovial fibroblasts in rheumatoid arthritis: lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destruction.
Arthritis Res.
2000;
2
59-64
-
41
Pap T, Nawrath M, Heinrich J. et al .
Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis.
Arthritis Rheum.
2004;
50
2794-2802
-
42
Pap T, Shigeyama Y, Kuchen S. et al .
Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis.
Arthritis Rheum.
2000;
43
1226-1232
-
43
Pierer M, Muller-Ladner U, Pap T, Neidhart M, Gay R E, Gay S.
The SCID mouse model: novel therapeutic targets - lessons from gene transfer.
Springer Semin Immunopathol.
2003;
25
65-78
-
44
Pierer M, Rethage J, Seibl R. et al .
Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands.
J Immunol.
2004;
172
1256-1265
-
45
Raingeaud J, Gupta S, Rogers J S. et al .
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.
J Biol Chem.
1995;
270
7420-7426
-
46
Ronday H K, Smits H H, Van Muijen G N. et al .
Difference in expression of the plasminogen activation system in synovial tissue of patients with rheumatoid arthritis and osteoarthritis.
Br J Rheumatol.
1996;
35
416-423
-
47
Rouse J, Cohen P, Trigon S. et al .
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins.
Cell.
1994;
78
1027-1037
-
48
Schedel J, Gay R E, Kuenzler P. et al .
FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis.
Arthritis Rheum.
2002;
46
1512-1518
-
49
Schedel J, Seemayer C A, Pap T. et al .
Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.
Gene Ther.
2004;
11
1040-1047
-
50
Seibl R, Kyburz D, Lauener R P, Gay S.
Pattern recognition receptors and their involvement in the pathogenesis of arthritis.
Curr Opin Rheumatol.
2004;
16
411-418
-
51
Sen M.
Wnt signalling in rheumatoid arthritis.
Rheumatology (Oxford).
2005;
44
708-713
-
52
Sen M, Chamorro M, Reifert J, Corr M, Carson D A.
Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation.
Arthritis Rheum.
2001;
44
772-781
-
53
Syrovets T, Jendrach M, Rohwedder A, Schule A, Simmet T.
Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activation.
Blood.
2001;
97
3941-3950
-
54
Vabulas R M, Ahmad-Nejad P, Ghose S, Kirschning C J, Issels R D, Wagner H.
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway.
J Biol Chem.
2002;
277
15107-15112
-
55
van der Laan W H, Pap T, Ronday H K. et al .
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor.
Arthritis Rheum.
2000;
43
1710-1718
-
56
van der Laan W H, Quax P H, Seemayer C A. et al .
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3.
Gene Ther.
2003;
10
234-242
-
57
Wakisaka S, Suzuki N, Saito N, Ochi T, Sakane T.
Possible correction of abnormal rheumatoid arthritis synovial cell function by jun D transfection in vitro.
Arthritis Rheum.
1998;
41
470-481
-
58
Woessner J F.
Matrix metalloproteinase inhibition: From the Jurassic to the third millennium.
Ann N Y Acad Sci.
1999;
878
388-403
-
59
Yamamoto A, Fukuda A, Seto H. et al .
Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts.
Arthritis Rheum.
2003;
48
2682-2692
-
60
Yamanishi Y, Boyle D L, Pinkoski M J. et al .
Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis.
Am J Pathol.
2002;
160
123-130
-
61
Yao Q, Wang S, Glorioso J C. et al .
Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation.
Mol Ther.
2001;
3
901-910
-
62
Zundel W, Schindler C, Haas-Kogan D. et al .
Loss of PTEN facilitates HIF-1-mediated gene expression.
Genes Dev.
2000;
14
391-396
Prof. Dr. Steffen Gay
Zentrum für Experimentelle Rheumatologie, Rheumaklinik und Institut für Physikalische Medizin, Universitätsklinikum Zürich
Gloriastraße 25
CH-8091 Zürich
Phone: 0041/44/2552962
Fax: 0041/44/2554170
Email: Steffen.Gay@usz.ch
