Iridium-Catalyzed Formation of Carbon-Carbon and Carbon-Heteroatom Bonds

Ryo Takeuchi; Satoko Kezuka

doi:10.1055/s-2006-950284

REVIEW

Iridium-Catalyzed Formation of Carbon-Carbon and Carbon-Heteroatom Bonds

Ryo Takeuchi*, Satoko Kezuka
Department of Chemistry and Biological Science, Aoyama Gakuin University, Fuchinobe, Sagamihara 229-8558, Japan
Fax: +81(42)7596493; e-Mail: takeuchi@chem.aoyama.ac.jp;

Abstract

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Abstract

The progress in catalytic organic synthesis with iridium was far behind that with rhodium or palladium in the early 1990s. However, many useful reactions have recently been reported, and iridium catalysts have now been recognized to be useful in organic synthesis. This review covers iridium-catalyzed carbon-carbon and carbon-heteroatom bond formation with particular emphasis on useful reactions for organic synthesis.

1 Introduction

2 Allylic Substitution

2.1 Allylic Alkylation

2.2 Allylic Amination

2.3 Allylic Etherification

3 Reaction of Alkynes

3.1 Cyclotrimerization of Alkynes

3.2 Cycloaddition of Enynes

3.3 Cycloisomerization of Enynes

3.4 Dimerization

3.5 Alkynylation

4 Alkylation with Alcohols

4.1 N-Alkylation

4.2 C-Alkylation

5 Aldol and Related Reactions

6 Carbonylation

7 Miscellaneous Reactions

8 Conclusion

Key words

iridium - asymmetric catalysis - allylations - alkynes - aldol reactions

Full Text

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