Abstract
A series of new, N-substituted azapodophyllotoxin derivatives were synthesized via a three-component reaction of an aldehyde, an enaminone and tetronic acid in glacial acetic acid, under microwave irradiation, without a catalyst. This new protocol has the advantages of shorter time, higher yields, lower cost and broader substrate scope, as well as easier operation.
Key words
microwave irradiation - tetronic acid - enaminone - N-substituted furo[3,4-b ]quinoline - azapodophyllotoxin
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15 X-ray crystal data for 4u ; CCDC 614893; Empirical formula C22 H22 FNO3 ; Formular weight 367.41; λ = 0.71073 Å; Crystal system = triclinic; Space group P-1; Unit cell dimensions a = 8.467 (6) Å, b = 9.213 (4) Å, c = 12.526 (6) Å, α = 82.806 (6)°, β = 75.484 (6)°, γ = 77.400(6)°; V = 922.7 (7) Å3 ; z-2; D(calculated) = 1.322 Mg/m3 ; µ (Mo
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16 X-ray crystal data for 4kk ; CCDC 614892; Empirical formula C26 H25 NO5 ; Formula weight 431.47; λ = 0.71073 Å; Crystal system = triclinic; Space group P-1; Unit cell dimensions a = 8.427 (9) Å, b = 11.453 (12) Å, c = 11.579 (12) Å, α = 95.909 (14)°, β = 100.870 (13)°, γ = 94.902 (15)°; V = 1085.3 (19) Å3 ; z-2, D (Calculated) = 1.320 3 ; µ (MoK
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