Indium Tribromide: An Efficient Catalyst for the Silylation of Hydroxy Groups by the Activation of Hexamethyldisilazane

J. S. Yadav; B. V. S. Reddy; A. K. Basak; G. Baishya; A. Venkat Narsaiah

doi:10.1055/s-2006-950322

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Synthesis 2006(22): 3831-3834
DOI: 10.1055/s-2006-950322

PAPER

Indium Tribromide: An Efficient Catalyst for the Silylation of Hydroxy Groups by the Activation of Hexamethyldisilazane [1]

J. S. Yadav*, B. V. S. Reddy, A. K. Basak, G. Baishya, A. Venkat Narsaiah
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
Fax: +91(40)27160512; e-Mail: yadavpub@iict.res.in;

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Publication History

Received 5 April 2006
Publication Date:
12 October 2006 (online)

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Abstract

A variety of substrates containing hydroxy groups have been protected as their corresponding trimethylsilyl ethers using 1,1,1,3,3,3-hexamethyldisilazane in the presence of indium tribromide. The catalyst indium tribromide activates the 1,1,1,3,3,3-hexamethyldisilazane and accelerates the reaction under mild reaction conditions at room temperature.

Keywords

indium tribromide - 1,1,1,3,3,3-hexamethyldisilazane - protection - hydroxy group - silylation

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IICT Communication No: 050724.