DMW - Deutsche Medizinische Wochenschrift, Inhaltsverzeichnis Dtsch Med Wochenschr 2006; 131(40): 2223-2228DOI: 10.1055/s-2006-951357 Aktuelle Diagnostik & Therapie | Review article Intensivmedizin © Georg Thieme Verlag KG Stuttgart · New York Beatmung bei Sepsis Mechanical ventilation of patients with sepsisR. Dembinski1 , R. Kopp1 , R. Kuhlen1 1Abteilung für Operative Intensivmedizin für Erwachsene, Universitätsklinikum Aachen, RWTH Aachen Artikel empfehlen Abstract Artikel einzeln kaufen Schlüsselwörter akutes Lungenversagen - ventilator-assoziierter Lungenschaden - nicht-invasive Beatmung - positiv-endexspiratorischer Druck - Entwöhnung - Bauchlage - Stickstoffmonoxid Key words acute lung injury - acute respiratory distress syndrome - ventilator-associated lung injury - non-invasive ventilation - positive end-expiratory pressure - weaning - prone position - nitric oxide Volltext Referenzen Literatur 1 Abraham E, Laterre P F, Garg R. et al . Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med. 2005; 353 1332-1341 2 Bernard G R, Artigas A, Brigham K L. et al. The American-European Consensus Conference on ARDS . Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994; 149 818-824 3 Brochard L, Rauss A, Benito S. et al . Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med. 1994; 150 896-903 4 Brower R G, Lanken P N, MacIntyre N. et al . Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004; 351 327-336 5 Dellinger R P, Carlet J M, Masur H. et al . Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004; 32 858-873 6 Ely E W, Baker A M, Dunagan D P. et al . Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med. 1996; 335 1864-1869 7 Esteban A, Alia I, Gordo F. et al . Extubation outcome after spontaneous breathing trials with T-tube or pressure support ventilation. Am J Respir Crit Care Med. 1997; 156 459-465 8 Esteban A, Alia I, Gordo F. et al . Prospective randomized trial comparing pressure-controlled ventilation and volume-controlled ventilation in ARDS. Chest. 2000; 117 1690-1696 9 Gattinoni L, Caironi P, Cressoni M. et al . Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med. 2006; 354 1775-1786 10 Gattinoni L, Pelosi P, Suter P M. et al . Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. Different syndromes?. Am J Respir Crit Care Med. 1998; 158 3-11 11 Gattinoni L, Tognoni G, Pesenti A. et al . Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med. 2001; 345 568-573 12 Guerin C, Gaillard S, Lemasson S. et al . Effects of systematic prone positioning in hypoxemic acute respiratory failure: a randomized controlled trial. JAMA. 2004; 292 2379-2387 13 Mancebo J, Fernandez R, Blanch L. et al . A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006; 173 1233-1239 14 Nieszkowska A, Lu Q, Vieira S. et al . Incidence and regional distribution of lung overinflation during mechanical ventilation with positive end-expiratory pressure. Crit Care Med. 2004; 32 1496-1503 15 Pfeiffer B, Hachenberg T, Wendt M, Marshall B. Mechanical ventilation with permissive hypercapnia increases intrapulmonary shunt in septic and nonseptic patients with acute respiratory distress syndrome. Crit Care Med. 2002; 30 285-289 16 Piehl M A, Brown R S. Use of extreme position changes in acute respiratory failure. Crit Care Med. 1976; 4 13-14 17 Pinhu L, Whitehead T, Evans T, Griffiths M. Ventilator-associated lung injury. Lancet. 2003; 361 332-340 18 Putensen C, Mutz N J, Putensen-Himmer G, Zinserling J. Spontaneous breathing during ventilatory support improves ventilation-perfusion distributions in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 1999; 159 1241-1248 19 Putensen C, Zech S, Wrigge H. et al . Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. Am J Respir Crit Care Med. 2001; 164 43-49 20 Reinhart K, Brunkhorst F M, Bone H G. et al . Diagnose und Therapie der Sepsis. S2-Leitlinien der Deutschen Sepsis-Gesellschaft e. V. (DSG) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI). Intensiv- und Notfallbehandlung. 2006; 1 3-32 21 Slutsky A S, Tremblay L N. Multiple system organ failure. Is mechanical ventilation a contributing factor?. Am J Respir Crit Care Med. 1998; 157 1721-1725 22 The Acute Respiratory Distress Syndrome Network . Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000; 342 1301-1308 23 Truwit J D, Bernard G R. Noninvasive ventilation - don’t push too hard. N Engl J Med. 2004; 350 2512-2515 24 Ware L B, Matthay M A. The acute respiratory distress syndrome. N Engl J Med. 2000; 342 1334-1349 Priv.-Doz. Dr. med. Rolf Dembinski Abteilung für Operative Intensivmedizin für Erwachsene, Universitätsklinikum Aachen, RWTH Aachen Pauwelsstraße 30 52074 Aachen