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DOI: 10.1055/s-2006-951725
Anti-HIV-1 Constituents from Leaves and Twigs of Cratoxylum arborescens
Publication History
Received: July 13, 2006
Accepted: September 15, 2006
Publication Date:
07 November 2006 (online)
Abstract
Two new xanthones, 1,3,8-trihydroxy-2,4-dimethoxyxanthone (1) and 1,7-dihydroxy-2,8-dimethoxyxanthone (2), along with twelve known compounds 3 - 14 were isolated from leaves and twigs of Cratoxylum arborescens. Compound 1, euxanthone (4), betulinic acid (8), lup-20(29)-ene-3β,30-diol (9), 3β-hydroxylup-20(29)-en-30-oic acid (10) and 3,4-dihydroxybenzoic acid (11) displayed anti-HIV-1 activities in the syncytium assay using Δ Tat/RevMC99 virus and the 1A2 cell line system (EC50 values between 3.9 and 32.2 μg/mL with TI ranging from 1.5 to 11.7), while 1,3,7-trihydroxy-6-methoxy-4,5-diisoprenylxanthone (3), 4, and 8 - 10 inhibited HIV-1 reverse transcriptase with IC50 values between 8.7 and 84.9 μg/mL.
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