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Aktuelle Ernährungsmedizin 2007; 32: S22-S29
DOI: 10.1055/s-2006-951866
DOI: 10.1055/s-2006-951866
Leitlinie Parenterale Ernährung der DGEM
© Georg Thieme Verlag KG Stuttgart · New York
6 Lipidemulsionen
Further Information
Publication History
Publication Date:
04 March 2008 (online)
Schlüsselwörter
Fettemulsionen - α-Tocopherol - hepatische Steatose - mehrfach ungesättigte Fettsäuren - kritisch Kranke
Key words
lipid emulsions - α-tocopherol - hepatic steatosis - polyunsaturated fatty acids - critically ill
Literatur
- 1 Deutsche Gesellschaft für Ernährung, Österreichische Gesellschaft für Ernährung, Schweizerische Gesellschaft für Ernährung, Schweizerische Gesellschaft für Ernährungsforschung, Schweizerische Vereinigung für Ernährung .Referenzwerte für die Nährstoffzufuhr. Frankfurt am Main; Umschau Braus Verlag 2000
- 2 Biolo G, Grimble G, Preiser J C. et al . Position paper of the ESICM Working Group on Nutrition and Metabolism. Metabolic basis of nutrition in intensive care unit patients: ten critical questions. Intensive Care Med. 2002; 28 1512-1520
- 3 Adolph M, Hailer S, Echart J. Serum phospholipid fatty acids in severely injured patients on total parenteral nutrition with medium chain/long chain triglyceride emulsions. Ann Nutr Metab. 1995; 39 251-260
- 4 Mascioli E A, Lopes S M, Champagne C, Driscoll D F. Essential fatty acid deficiency and home total parenteral nutrition patients. Nutrition. 1996; 12 245-249
- 5 Friedman Z, Danon A, Stahlman M T, Oates J A. Rapid onset of essential fatty acid deficiency in the newborn. Pediatrics. 1976; 58 640-649
- 6 Koletzko B. Essentielle Fettsäuren: Bedeutung für Medizin und Ernährung. Akt Endokrinol Stoffw. 1986; 7 18-27
-
7 Koletzko B, Innis S M.
Lipids. In: Tsang R, Uauy R, Koletzko B, Zlotkin S (eds) Nutrition of the preterm infant: scientific basis and practical guidelines. Cincinnati, Ohio; Digital Educational Publishing 2005: 97-139 - 8 Tappy L, Schwarz J M, Schneiter P. et al . Effects of isoenergetic glucose-based or lipid-based parenteral nutrition on glucose metabolism, de novo lipogenesis, and respiratory gas exchanges in critically ill patients. Crit Care Med. 1998; 26 860-867
- 9 Battistella F D, Widergren J T, Anderson J T, Siepler J K, Weber J C, MacColl K. A prospective, randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition. J Trauma. 1997; 43 52-58
- 10 Heyland D K, Montalvo M, MacDonald S, Keefe L, Su X Y, Drover J W. Total parenteral nutrition in the surgical patient: a meta-analysis. Can J Surg. 2001; 44 102-111
- 11 Stouthard J M, Endert E, Romijn J A, Sauerwein H P. Infusion of long-chain or medium-chain triglycerides inhibits peripheral glucose metabolism in men. JPEN J Parenter Enteral Nutr. 1994; 18 436-441
- 12 Tissot S, Normand S, Khalfallah Y. et al . Effects of a continuous lipid infusion on glucose metabolism in critically ill patients. Am J Physiol. 1995; 269 E753-E758
- 13 Craig R M, Coy D, Green R, Meersman R, Rubin H, Janssen I. Hepatotoxicity related to total parenteral nutrition: comparison of low-lipid and lipid-supplemented solutions. J Crit Care. 1994; 9 111-113
- 14 Baker A L, Rosenberg I H. Hepatic complications of total parenteral nutrition. Am J Med. 1987; 82 489-497
- 15 Driscoll D F, Blackburn G L. Total parenteral nutrition 1990. A review of its current status in hospitalised patients, and the need for patient-specific feeding. Drugs. 1990; 40 346-363
- 16 Jeejeebhoy K N, Anderson G H, Nakhooda A F, Greenberg G R, Sanderson I, Marliss E B. Metabolic studies in total parenteral nutrition with lipid in man. Comparison with glucose. J Clin Invest. 1976; 57 125-136
- 17 Sheldon G F, Peterson S R, Sanders R. Hepatic dysfunction during hyperalimentation. Arch Surg. 1978; 113 504-508
- 18 Reif S, Tano M, Oliverio R, Young C, Rossi T. Total parenteral nutrition-induced steatosis: reversal by parenteral lipid infusion. JPEN J Parenter Enteral Nutr. 1991; 15 102-104
- 19 Balistreri W F, Bove K E. Hepatobiliary consequences of parenteral alimentation. Prog Liver Dis. 1990; 9 567-601
- 20 Tulikoura I, Huikuri K. Morphological fatty changes and function of the liver, serum free fatty acids, and triglycerides during parenteral nutrition. Scand J Gastroenterol. 1982; 17 177-185
- 21 Koletzko B, Goulet O, Hunt J, Krohn K, Shamir R. 1. Guidelines on Paediatric Parenteral Nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), Supported by the European Society of Paediatric Research (ESPR). J Pediatr Gastroenterol Nutr. 2005; 41, Suppl 2 S1-S87
- 22 Reimund J M, Duclos B, Arondel Y, Baumann R. Persistent inflammation and immune activation contribute to cholestasis in patients receiving home parenteral nutrition. Nutrition. 2001; 17 300-304
- 23 Bindl L, Lutjohann D, Buderus S, Lentze M J, Bergmann K. High plasma levels of phytosterols in patients on parenteral nutrition: a marker of liver dysfunction. J Pediatr Gastroenterol Nutr. 2000; 31 313-316
- 24 Clayton P T, Bowron A, Mills K A, Massoud A, Casteels M, Milla P J. Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease. Gastroenterology. 1993; 105 1806-1813
- 25 Clayton P T, Whitfield P, Iyer K. The role of phytosterols in the pathogenesis of liver complications of pediatric parenteral nutrition. Nutrition. 1998; 14 158-164
- 26 Deitel M, Kaminsky V M, Fuksa M. Growth of common bacteria and Candida albicans in 10 % soybean oil emulsion. Can J Surg. 1975; 18 531-535
- 27 Gilbert M, Gallagher S C, Eads M, Elmore M F. Microbial growth patterns in a total parenteral nutrition formulation containing lipid emulsion. JPEN J Parenter Enteral Nutr. 1986; 10 494-497
- 28 Keammerer D, Mayhall C G, Hall G O, Pesko L J, Thomas R B. Microbial growth patterns in intravenous fat emulsions. Am J Hosp Pharm. 1983; 40 1650-1653
- 29 Melly M A, Meng H C, Schaffner W. Microbiol growth in lipid emulsions used in parenteral nutrition. Arch Surg. 1975; 110 1479-1481
- 30 Fox M, Molesky M, Aerde J E Van, Muttitt S. Changing parenteral nutrition administration sets every 24 h versus every 48 h in newborn infants. Can J Gastroenterol. 1999; 13 147-151
- 31 Bennett S N, McNeil M M, Bland L A. et al . Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med. 1995; 333 147-154
- 32 Didier M E, Fischer S, Maki D G. Total nutrient admixtures appear safer than lipid emulsion alone as regards microbial contamination: growth properties of microbial pathogens at room temperature. JPEN J Parenter Enteral Nutr. 1998; 22 291-296
- 33 Pironi L, Ruggeri E, Zolezzi C. et al . Lipid peroxidation and antioxidant status in adults receiving lipid-based home parenteral nutrition. Am J Clin Nutr. 1998; 68 888-893
- 34 Göbel Y, Koletzko B, Böhles H J. et al . Parenteral fat emulsions based on olive and soybean oils: a randomized clinical trial in preterm infants. J Pediatr Gastroenterol Nutr. 2003; 37 161-167
- 35 Steephen A C, Traber M G, Ito Y, Lewis L H, Kayden H J, Shike M. Vitamin E status of patients receiving long-term parenteral nutrition: is vitamin E supplementation adequate?. JPEN J Parenter Enteral Nutr. 1991; 15 647-652
- 36 Manuel-y-Keenoy B, Nonneman L, Bosscher H De. et al . Effects of intravenous supplementation with alpha-tocopherol in patients receiving total parenteral nutrition containing medium- and long-chain triglycerides. Eur J Clin Nutr. 2002; 56 121-128
- 37 Goulet O, Potter S de, Antebi H. et al . Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a double-blind randomized study. Am J Clin Nutr. 1999; 70 338-345
- 38 Huschak G, Zur N K, Hoell T, Riemann D, Mast H, Stuttmann R. Olive oil based nutrition in multiple trauma patients: a pilot study. Intensive Care Med. 2005; 31 1202-1208
- 39 Kinsella J E, Lokesh B. Dietary lipids, eicosanoids, and the immune system. Crit Care Med. 1990; 18 S94-S113
- 40 Palmblad J. Intravenous lipid emulsions and host defense - a critical review. Clin Nutr. 1991; 10 303-308
- 41 Llop J, Sabin P, Garau M. et al . The importance of clinical factors in parenteral nutrition-associated hypertriglyceridemia. Clin Nutr. 2003; 22 577-583
-
42 Carpentier Y A.
Lipids. In: Sobotka L, Allison SP, Fürst P, Meier R, Pertkiewicz M, Soeters PB (eds) Basics in clinical nutrition. Prag; Galén 2004: 153-156 -
43 Druml W.
Fett in der parenteralen Ernährung. In: Schauder P, Ollenschläger G (Hrsg) Ernährungsmedizin. Prävention und Therapie. München; Urban & Fischer 2006: 310-317 - 44 Sane S, Baba M, Kusano C, Shirao K, Yamada H, Aikou T. Influence of exogenous fat emulsion on pulmonary gas exchange after major surgery. World J Surg. 2002; 26 297-302
- 45 Suchner U, Katz D P, Furst P. et al . Impact of sepsis, lung injury, and the role of lipid infusion on circulating prostacyclin and thromboxane A(2). Intensive Care Med. 2002; 28 122-129
- 46 Carpentier Y A, Richelle M, Bury J. Phospholipid excess of fat emulsions slows triglyceride removal and increases lipoprotein remodelling. Arteriosclerosis. 1987; 7 541a
- 47 Garcia-de-Lorenzo A, Lopez-Martinez J, Planas M. et al . Safety and metabolic tolerance of a concentrated long-chain triglyceride lipid emulsion in critically ill septic and trauma patients. JPEN J Parenter Enteral Nutr. 2003; 27 208-215
- 48 Haumont D, Richelle M, Deckelbaum R J, Coussaert E, Carpentier Y A. Effect of liposomal content of lipid emulsions on plasma lipid concentrations in low birth weight infants receiving parenteral nutrition. J Pediatr. 1992; 121 759-763
- 49 Tashiro T, Mashima Y, Yamamori H, Sanada M, Nishizawa M, Okui K. Intravenous intralipid 10 % vs. 20 %, hyperlipidemia, and increase in lipoprotein X in humans. Nutrition. 1992; 8 155-160
- 50 Calder P C, Yaqoob P, Thies F, Wallace F A, Miles E A. Fatty acids and lymphocyte functions. Br J Nutr. 2002; 87, Suppl 1 S31-S48
- 51 Mayer K, Grimm H, Grimminger F, Seeger W. Parenteral nutrition with n-3 lipids in sepsis. Br J Nutr. 2002; 87, Suppl 1 S69-S75
- 52 Waitzberg D L, Bellinati-Pires R, Salgado M M. et al . Effect of total parenteral nutrition with different lipid emulsions of human monocyte and neutrophil functions. Nutrition. 1997; 13 128-132
- 53 Waitzberg D L, Lotierzo P H, Logullo A F, Torrinhas R S, Pereira C C, Meier R. Parenteral lipid emulsions and phagocytic systems. Br J Nutr. 2002; 87, Suppl 1 S49-S57
- 54 Furukawa K, Yamamori H, Takagi K. et al . Influences of soybean oil emulsion on stress response and cell-mediated immune function in moderately or severely stressed patients. Nutrition. 2002; 18 235-240
- 55 Heyland D K, MacDonald S, Keefe L, Drover J W. Total parenteral nutrition in the critically ill patient: a meta-analysis. JAMA. 1998; 280 2013-2019
- 56 Mayer K, Meyer S, Reinholz-Muhly M. et al . Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans. J Immunol. 2003; 171 4837-4843
- 57 Chambrier C, Bannier E, Lauverjat M, Drai J, Bryssine S, Bouletreau P. Replacement of long-chain triglyceride with medium-chain triglyceride/long-chain triglyceride lipid emulsion in patients receiving long-term parenteral nutrition: effects on essential fatty acid status and plasma vitamin K1 levels. JPEN J Parenter Enteral Nutr. 2004; 28 7-12
- 58 Lehner F, Demmelmair H, Röschinger W. et al . Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. J Lipid Res. 2006; 47 404-411
- 59 Martin-Pena G, Culebras J M, De P, Barro-Ordovas J P, Catala-Pizarro R, Ruiz-Galiana J. Effects of 2 lipid emulsions (LCT versus MCT/LCT) on the fatty acid composition of plasma phospholipid: a double-blind randomized trial. JPEN J Parenter Enteral Nutr. 2002; 26 30-41
- 60 Hailer S, Jauch K W, Wolfram G. Influence of different fat emulsions with 10 or 20 % MCT/LCT or LCT on lipoproteins in plasma of patients after abdominal surgery. Ann Nutr Metab. 1998; 42 170-180
- 61 Rubin M, Naor N, Sirota L. et al . Are bilirubin and plasma lipid profiles of premature infants dependent on the lipid emulsion infused?. J Pediatr Gastroenterol Nutr. 1995; 21 25-30
- 62 Treskova E, Carpentier Y A, Ramakrishnan R, Al Haideri M, Seo T, Deckelbaum R J. Blood clearance and tissue uptake of intravenous lipid emulsions containing long-chain and medium-chain triglycerides and fish oil in a mouse model. JPEN J Parenter Enteral Nutr. 1999; 23 253-257
- 63 Ball M J. Parenteral nutrition in the critically ill: use of a medium chain triglyceride emulsion. Intensive Care Med. 1993; 19 89-95
- 64 Garnacho-Montero J, Ortiz-Leyba C, Jimenez-Jimenez F J. et al . Clinical and metabolic effects of two lipid emulsions on the parenteral nutrition of septic patients. Nutrition. 2002; 18 134-138
- 65 Demirer S, Aydintug S, Ustun C. et al . Comparison of the efficacy of medium chain triglycerides with long chain triglycerides in total parenteral nutrition in patients with hematologic malignancies undergoing peripheral blood stem cell transplantation. Clin Nutr. 2000; 19 253-258
- 66 Mascioli E A, Randall S, Porter K A. et al . Thermogenesis from intravenous medium-chain triglycerides. JPEN J Parenter Enteral Nutr. 1991; 15 27-31
- 67 Mu H, Porsgaard T. The metabolism of structured triacylglycerols. Prog Lipid Res. 2005; 44 430-448
- 68 Lindgren B F, Ruokonen E, Magnusson-Borg K, Takala J. Nitrogen sparing effect of structured triglycerides containing both medium-and long-chain fatty acids in critically ill patients; a double blind randomized controlled trial. Clin Nutr. 2001; 20 43-48
- 69 Sandstrom R, Hyltander A, Korner U, Lundholm K. Structured triglycerides were well tolerated and induced increased whole body fat oxidation compared with long-chain triglycerides in postoperative patients. JPEN J Parenter Enteral Nutr. 1995; 19 381-386
- 70 Chambrier C, Guiraud M, Gibault J P, Labrosse H, Bouletreau P. Medium- and long-chain triacylglycerols in postoperative patients: structured lipids versus a physical mixture. Nutrition. 1999; 15 274-277
- 71 Kruimel J W, Naber T H, Vliet J A van der, Carneheim C, Katan M B, Jansen J B. Parenteral structured triglyceride emulsion improves nitrogen balance and is cleared faster from the blood in moderately catabolic patients. JPEN J Parenter Enteral Nutr. 2001; 25 237-244
- 72 Rubin M, Moser A, Vaserberg N. et al . Structured triacylglycerol emulsion, containing both medium- and long-chain fatty acids, in long-term home parenteral nutrition: a double-blind randomized cross-over study. Nutrition. 2000; 16 95-100
- 73 Thomas-Gibson S, Jawhari A, Atlan P, Brun A L, Farthing M, Forbes A. Safe and efficacious prolonged use of an olive oil-based lipid emulsion (ClinOleic) in chronic intestinal failure. Clin Nutr. 2004; 23 697-703
- 74 Granato D, Blum S, Rossle C, Boucher J Le, Malnoe A, Dutot G. Effects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro. JPEN J Parenter Enteral Nutr. 2000; 24 113-118
- 75 Reimund J M, Arondel Y, Joly F, Messing B, Duclos B, Baumann R. Potential usefulness of olive oil-based lipid emulsions in selected situations of home parenteral nutrition-associated liver disease. Clin Nutr. 2004; 23 1418-1425
- 76 Versleijen M, Roelofs H, Preijers F, Roos D, Wanten G. Parenteral lipids modulate leukocyte phenotypes in whole blood, depending on their fatty acid composition. Clin Nutr. 2005; 24 822-829
- 77 Garcia-de-Lorenzo A, Denia R, Atlan P. et al . Parenteral nutrition providing a restricted amount of linoleic acid in severely burned patients: a randomised double-blind study of an olive oil-based lipid emulsion v. medium/long-chain triacylglycerols. Br J Nutr. 2005; 94 221-230
- 78 Gadek J E, DeMichele S J, Karlstad M D. et al . Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. Crit Care Med. 1999; 27 1409-1420
- 79 Pscheidl E, Schywalsky M, Tschaikowsky K, Boke-Prols T. Fish oil-supplemented parenteral diets normalize splanchnic blood flow and improve killing of translocated bacteria in a low-dose endotoxin rat model. Crit Care Med. 2000; 28 1489-1496
- 80 Morlion B J, Torwesten E, Lessire H. et al . The effect of parenteral fish oil on leukocyte membrane fatty acid composition and leukotriene-synthesizing capacity in patients with postoperative trauma. Metabolism. 1996; 45 1208-1213
- 81 Köller M, Senkal M, Kemen M, König W, Zumtobel V, Muhr G. Impact of omega-3 fatty acid enriched TPN on leukotriene synthesis by leukocytes after major surgery. Clin Nutr. 2003; 22 59-64
- 82 Schauder P, Rohn U, Schafer G, Korff G, Schenk H D. Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period. Br J Nutr. 2002; 87, Suppl 1 S103-S110
- 83 Roulet M, Frascarolo P, Pilet M, Chapuis G. Effects of intravenously infused fish oil on platelet fatty acid phospholipid composition and on platelet function in postoperative trauma. JPEN J Parenter Enteral Nutr. 1997; 21 296-301
- 84 Heller A R, Fischer S, Rossel T. et al . Impact of n-3 fatty acid supplemented parenteral nutrition on haemostasis patterns after major abdominal surgery. Br J Nutr. 2002; 87, Suppl 1 S95-S101
- 85 Heller A R, Rössler S, Litz R J, Stehr S N, Heller S C, Koch R, Koch T. Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med. 2006; 34 972-979
- 86 Weiss G, Meyer F, Matthies B, Pross M, Koenig W, Lippert H. Immunomodulation by perioperative administration of n-3 fatty acids. Br J Nutr. 2002; 87, Suppl 1 S89-S94
- 87 Heller A R, Rossel T, Gottschlich B. et al . Omega-3 fatty acids improve liver and pancreas function in postoperative cancer patients. Int J Cancer. 2004; 111 611-616
- 88 Grecu I, Mirea L, Grintescu I. Parenteral fish oil supplementation in patients with abdominal sepsis. Clin Nutr. 2003; 22 S23
- 89 Heller A R, Rössler S, Litz R J. et al . Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med. 2006; 34 972-979
- 90 Planas M, Porta I, Sagrista M L, Mora M, Padro J B, Pico M. Fatty acid composition of platelet membrane lipids after administration of two different fat emulsions in critically ill patients. Intensive Care Med. 1999; 25 395-398
- 91 Wichman M W, Thul P, Czarnetzki H D, Morlion B, Kemen M, Jauch K W. Evaluation of clinical safety and beneficial effects of a fish oil containing lipid emulsion (Lipoplus, MLF 541): data from a prospective, randomized, multicenter trial. Crit Care Med 2007 35 im Druck
- 92 Singer P, Zolotarski V, Yussim A, Lustig S, Attal-Singer J, Cohen J. Renal effects of parenteral fish oil administered to heart-beating organ donors and renal-transplant recipients: a tolerance study. Clin Nutr. 2004; 23 597-603
- 93 Schlotzer E, Kanning U. Elimination and tolerance of a new parenteral lipid emulsion (SMOF) - a double-blind cross-over study in healthy male volunteers. Ann Nutr Metab. 2004; 48 263-268
- 94 Mertes N, Grimm H, Fürst P, Stehle P. Safety and efficacy of a new parenteral lipid emulsion (SMOFlipid) in surgical patients: a randomized, double-blind, multicenter study. Ann Nutr Metab. 2006; 50 253-259
- 95 Schulzki C, Mertes N, Wenn A. et al . Effect of a new type of lipid emulsion based on soybean oil, MCT, olive oil and fish oil (SMOF) in surgical patients. Clin Nutr. 1999; 18, (Suppl 1) 7
- 96 Grimm H, Mertes N, Goeters C. et al . Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients. Eur J Nutr. 2006; 45 55-60
- 97 Antebi H, Mansoor O, Ferrier C. et al . Liver function and plasma antioxidant status in intensive care unit patients requiring total parenteral nutrition: comparison of 2 fat emulsions. JPEN J Parenter Enteral Nutr. 2004; 28 142-148