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Dtsch Med Wochenschr 2006; 131(42): 2355-2358
DOI: 10.1055/s-2006-955016
DOI: 10.1055/s-2006-955016
Prinzip & Perspektive | Review article
Grundlagenforschung
© Georg Thieme Verlag KG Stuttgart · New York
CD8+ T-Zelldifferenzierung bei Virusinfektionen
CD8+ T cell differentiation in viral infectionsFurther Information
Publication History
eingereicht: 10.4.2006
akzeptiert: 6.7.2006
Publication Date:
17 October 2006 (online)

Schlüsselwörter
CD8+ T-Zellen - Virusinfektionen - Immunpathogenese
Key words
CD8+ T cells - viral infections - immunopathogenesis
Literatur
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- 2 Barber D L, Wherry E J, Masopust D. et al . Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006; 439 682-687
- 3 Boettler T, Panther E, Bengsch B. et al . Expression of IL-7 receptor a chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells in acute resolving hepatitis B virus infection. J Virol. 2006; 80 3532-3540
- 4 Gattinoni L, Klebanoff C A, Palmer D C. et al . Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. J Clin Invest. 2005; 115 1616-1626
- 5 Kaech S M, Tan J T, Wherry E J, Konieczny B T, Surh C D, Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol. 2003; 4 1191-1198
- 6 Klenerman P, Hill A. T cells and viral persistence: lessons from diverse infections. Nat Immunol. 2005; 6 873-879
- 7 McMichael A J, Rowland-Jones S L. Cellular immune responses to HIV. Nature. 2001; 410 980-987
- 8 Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol. 2005; 5 215-229
- 9 Schmitz J E, Kuroda M J, Santra S. et al . Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science. 1999; 283 857-860
- 10 Shoukry N H, Grakoui A, Houghton M. et al . Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med. 2003; 197 1645-1655
- 11 Thimme R, Wieland S, Steiger C. et al . CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol. 2003; 77 68-76
- 12 Thimme R, Appay V, Koschella M. et al . Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J Virol. 2005; 79 12112-12116
- 13 Thimme R, Lohmann V, Weber F. A target on the move: Innate and adaptive immune escape strategies of hepatitis C virus. Antiviral Res. 2006; 69 129-141
- 14 van Leeuwen E M, de Bree G J, Remmerswaal E B. et al . IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. Blood. 2005; 106 2091-2098
Prof. Dr. med. Robert Thimme
Universitätsklinikum Freiburg, Abteilung Innere Medizin II
Hugstetter Straße 55
79106 Freiburg
Phone: 0761/2703280
Fax: 0761/2703372
Email: thimme@med1.ukl.uni-freiburg.de