A Simple Protocol for the Generation of Methyl(trifluoromethyl)dioxirane

Abstract

Methyl(trifluoromethyl)dioxirane, generated from an aqueous solution of 1,1,1-trifluoroacetone hydrate, sodium bicarbonate and peroxomonosulfate, is removed from the reaction mixture by the evolved gases and applied to the oxidation of substrates placed in a second reaction zone. The method is simple and robust, and allows for the application of methyl(trifluoromethyl)dioxirane in oxidation reactions on a preparative scale.

dioxiranes - methyl(trifluoromethyl)dioxirane - oxidation - oxygenation - synthesis

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