Prostasomes, Angiogenesis, and Tissue Factor

George H. Delves; Alistair B. Stewart; Alan J. Cooper; Bashir A. Lwaleed

doi:10.1055/s-2006-958465

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2007; 33(1): 075-079
DOI: 10.1055/s-2006-958465

Prostasomes, Angiogenesis, and Tissue Factor

George H. Delves¹ , Alistair B. Stewart² , Alan J. Cooper¹ , Bashir A. Lwaleed³

¹School of Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
²Pyrah Department of Urology, St. James' University Hospital Leeds, Leeds, United Kingdom
³Department of Urology, Southampton University Hospitals NHS Trust, Southampton, United Kingdom

Abstract

ABSTRACT

Prostasomes are membrane-bound secretory vesicles produced by prostatic epithelial cells. They are known to carry many proteins, including tissue factor, and have membranes unusually rich in cholesterol and sphingomyelin. Prostasomes have well-documented effects on fertility, promoting sperm motility, stabilizing the acrosome reaction, and facilitating immunosuppression. This article reviews the evidence of the effects of prostasomes on in vitro angiogenesis assays, and the mechanism by which these effects occur. Seminal prostasomes seem to inhibit angiogenesis, whereas the equivalent particles released by malignant prostate cells promote angiogenesis. In both cases, the effects seem preserved after heat treatment to denature the protein content, suggesting an important role for lipid transfer, in particular, transfer of sphingomyelin.

KEYWORDS

Prostasomes - angiogenesis - sphingomyelin - tissue factor

Full Text

References

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Dr. Bashir A Lwaleed

Department of Urology, Central Block, E Level, West Wing, Mailpoint 67, Southampton University Hospitals

Southampton, Tremona Road, SO16 6YD, United Kingdom

Email: bashir@soton.ac.uk