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Semin Liver Dis 2007; 27(1): 013-027
DOI: 10.1055/s-2006-960168
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Genetics, Genomics, and Proteomics: Implications for the Diagnosis and the Treatment of Chronic Hepatitis C

Tarik Asselah1 , Ivan Bièche2 , Valérie Paradis3 , Pierre Bedossa3 , Michel Vidaud2 , Patrick Marcellin1
  • 1Service d'Hépatologie and INSERM U773, CRB3, University of Paris VII, AP-HP Hôpital Beaujon, Clichy, France
  • 2INSERM U745, University of Paris V, France
  • 3Service d'Anatomie Pathologique, AP-HP Hôpital Beaujon, Clichy, France
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Publication History

Publication Date:
12 February 2007 (online)

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ABSTRACT

Hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. The severity of disease varies widely from mild illness to cirrhosis and hepatocellular carcinoma. The progression of liver fibrosis in HCV patients determines the prognosis and, thus, the need for and urgency of therapy. In addition to viral and environmental behavioral factors, host genetic diversity is believed to contribute to the spectrum of clinical outcomes of patients chronically infected with HCV. The sequencing of the human genome together with the development of high-throughput technologies has provided opportunities to distinguish discrete subsets of HCV disease and predict the disease outcome or the response to therapy. This article reviews genetic, genomic, and proteomic aspects associated with the natural history of HCV infection (i.e., viral clearance, fibrosis progression) and the response to therapy.

KEYWORDS

Microarray - HLA loci - fibrosis progression - prediction - pegylated interferon

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Prof. Patrick Marcellin

Service d'Hépatologie, Hôpital Beaujon

100 Bd du Gl Leclerc, 92110 Clichy, France