Genomics and Signaling Pathways in Hepatocellular Carcinoma

Augusto Villanueva; Philippa Newell; Derek Y. Chiang; Scott L. Friedman; Josep M. Llovet

doi:10.1055/s-2006-960171

Seminars in Liver Disease, Inhaltsverzeichnis

Semin Liver Dis 2007; 27(1): 055-076
DOI: 10.1055/s-2006-960171

Genomics and Signaling Pathways in Hepatocellular Carcinoma

Augusto Villanueva¹ , Philippa Newell¹ , Derek Y. Chiang² ^, ³ , Scott L. Friedman¹ , Josep M. Llovet¹ ^, ⁴

¹Mount Sinai Liver Cancer Program, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York
²Broad Institute of MIT and Harvard, Cambridge, Massachusetts
³Dana-Farber Cancer Institute, Boston, Massachusetts
⁴BCLC Group, IDIBAPS, Liver Unit, Hospital Clinic, Barcelona, Spain

Abstract

ABSTRACT

Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients and has become a major health problem in developed countries. There is an elemental understanding of the genes and signaling pathways involved in the initiation and progression of this neoplasm. The current hypothesis of the HCC cell origin includes both somatic cells (hepatocytes) and stem cells/progenitor cells. Unlike that in other malignancies such as breast, brain, or hematopoietic cancers, the implication of cancer stem cells in HCC pathogenesis is not yet supported by consistent data. Analysis of somatic genetic alterations and gene expression profiles in HCC samples has provided relevant information on the genes involved in hepatocarcinogenesis, pinpointing a seminal molecular classification of the disease. Nonetheless, a comprehensive genomic analysis of HCC samples using high-resolution platforms in precisely annotated HCCs is clearly needed. Recent data have identified different signaling pathways in liver carcinogenesis (e.g., Wnt-βCatenin, Hedgehog, tyrosine kinase receptor-related pathways), providing an important potential source of novel molecular targets for new therapies. This review summarizes the most relevant information regarding structural and functional alterations in HCC and describes some of the key signaling pathways implicated in hepatocarcinogenesis.

KEYWORDS

Liver cancer - genomics - signaling pathway

Volltext

Referenzen

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Josep M LlovetM.D.

Division of Liver Diseases, Mount Sinai School of Medicine

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