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J Reconstr Microsurg 1996; 12(1): 39-46
DOI: 10.1055/s-2007-1006451
ORIGINAL ARTICLE

© 1996 by Thieme Medical Publishers, Inc.

The Effect of Beraprost Sodium on the Survival of Subcutaneous Transferred Jejunum after Vascular Pedicle Interruption in a Rat Model

Konstantinos Alexandrou, Yuiro Hata, Kazunori Matsuka, Osamu Ito, Hidenori Matsuda, Hiromi Furuichi, Nobuko Ishizu
  • Department of Plastic Surgery, Kagawa Medical School, Japan
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Publication History

Accepted for publication 1995

Publication Date:
08 March 2008 (online)

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ABSTRACT

Beraprost sodium, a stable PGI2 analog, having antiplatelet aggregation and vasodilating actions, was tested in a rat subcutaneous heterotopic jejunal model for its ability to improve survival after vascular pedicle interruption. Forty Sprague-Dawley rats were divided into four groups: Group 1 (control, ligation of pedicle on postoperative day 5); Group 2 (Beraprost sodium, ligation on day 5); Group 3 (control, ligation on day 7); and Group 4 (Beraprost sodium, ligation on day 7). The resulting viability rates were: Group 1 = 0 percent, Group 2 = 40 percent, Group 3 = 30 percent, Group 4 = 90 percent.

These results indicate that the administration of Beraprost sodium facilitates the neovascularization of the transferred intestine and shortens the time required for viability of the transferred tissue, after interruption of the vascular pedicle.