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Synthesis 2007(10): 1475-1480  
DOI: 10.1055/s-2007-966047
PAPER
© Georg Thieme Verlag Stuttgart · New York

New Synthons for the Preparation of Arylimidazolines and Tetrahydro­pyrimidine Analogues

Ekaterina Paliakov, Thomas Elleboe, David W. Boykin*
Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA
Fax: +1(404)6511416; e-Mail: dboykin@gsu.edu;
Further Information

Publication History

Received 15 December 2006
Publication Date:
02 May 2007 (online)

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Abstract

An adaptation of the Fujioka method for the efficient synthesis of arylimidazolines from aryl aldehydes was used for the synthesis of aryltetrahydropyrimidines. tert-Butoxycarbonyl-protected bromo- or iodophenyl-substituted imidazolines and tetrahydropyrimidines both undergo Suzuki coupling reactions with arylboronic acids in good yields.

Key words

imidazolines - tetrahydropyrimidines - protecting groups - Suzuki coupling - amidine heterocycles

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