Planta Med 2007; 73(4): 380-383
DOI: 10.1055/s-2007-967163
Letter
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Glycosides of 20-Deoxy Derivatives of Jujubogenin and Pseudojujubogenin from Bacopa monniera

Rahul S. Pawar1 , Shabana I. Khan1 , Ikhlas A. Khan1 , 2
  • 1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS, USA
  • 2Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS, USA
Further Information

Publication History

Received: August 30, 2006 Revised: February 8, 2007

Accepted: February 13, 2007

Publication Date:
29 March 2007 (online)

Abstract

A detailed phytochemical investigation of an extract of Bacopa monniera resulted in the isolation of two new dammarane glycosides along with eight known compounds. They have been identified as glycosides of the 20-deoxy derivatives of jujubogenin and pseudojujubogenin. The structures were established by different spectroscopic methods that included 1D and 2D NMR experiments. The compounds were tested for their cytotoxicity, antileishmanial, antimalarial, antioxidant, and anti-inflammatory activities. Only few compounds exhibited mild to moderate cytotoxicity towards non-cancerous kidney cell lines.

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Ikhlas A. Khan

National Center for Natural Products Research

University of Mississippi

University

MS 38677

USA

Phone: +1-662-915-7821

Fax: +1-662-915-7989

Email: ikhan@olemiss.edu