Abstract
Three new epoxyfuranoid lignans, 4α,5α-epoxybeilschmin A (1), 4α,5α-epoxybeilschmin B (2), and beilschmin D (3), together with nine known compounds have been isolated from the leaves of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (4) and beilschmin B (5) exhibited potent antitubercular activities (MICs = 2.5 and 7.5 μg/mL, respectively) against Mycobacterium tuberculosis 90 - 221 387 in vitro.
Key words
Beilschmiedia tsangii
- Lauraceae - epoxyfuranoid lignans - 4α,5α-epoxybeilschmin A - 4α,5α-epoxybeilschmin B - beilschmin D - antitubercular activity
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Dr. J. J. Chen
Graduate Institute of Pharmaceutical Technology
Tajen University
Pingtung 907
Taiwan
Fax: +886-8-762-5308
Email: jjchen@mail.tajen.edu.tw
