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DOI: 10.1055/s-2007-967196
© Georg Thieme Verlag KG Stuttgart · New York
New Dihydrochalcones and Anti-Platelet Aggregation Constituents from the Leaves of Muntingia calabura
Publication History
Received: November 1, 2006
Revised: January 8, 2007
Accepted: April 10, 2007
Publication Date:
22 May 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/200706/lookinside/thumbnails/10.1055-s-2007-967196-1.jpg)
Abstract
Two new dihydrochalcones, 2,3-dihydroxy-4,3′,4′,5′-tetramethoxydihydrochalcone (1) and 4,2′,4′-trihydroxy-3′-methoxydihydrochalcone (2), and a new flavanone, (2R,3R)-(-)-3,5-dihydroxy-6,7-dimethoxyflavanone (3), together with nineteen known compounds have been isolated from the leaves of Muntingia calabura. The structures of three new compounds were determined through spectral analyses including extensive 2D-NMR data. Among the isolates, 2,3-dihydroxy-4,3′,4′,5′-tetramethoxydihydrochalcone, 5,7-dihydroxy-3-methoxyflavone, 5,7-dihydroxy-6-methoxyflavone, 5,4′-dihydroxy-3,7-dimethoxyflavone, (2S)-7,8,3′,4′,5′-pentamethoxyflavan, (2S)-5′-hydroxy-7,8,3′,4′-tetramethoxyflavan, and methyl gallate exhibited significant anti-platelet aggregation activity in vitro.
Key words
Muntingia calabura - Tiliaceae - dihydrochalcones - 2,3-dihydroxy-4,3′,4′,5′-tetramethoxydihydrochalcone - 4,2′,4′-trihydroxy-3′-methoxydihydrochalcone - flavanone - (2R,3R)-(-)-3,5-dihydroxy-6,7-dimethoxyflavanone - anti-platelet aggregation activity
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Dr. J. J. Chen
Department of Pharmacy
Tajen University
Pingtung 907
Taiwan
Phone: +886-8-762-4002 ext. 332
Fax: +886-8-7625308
Email: jjchen@mail.tajen.edu.tw