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Osteosynthesis and Trauma Care 2007; 15(1): 21-25
DOI: 10.1055/s-2007-970065
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Endothelial Permeability and 3-Nitrotyrosine in Major Burns

B. Schlegel 1 , C. Uhlig 2 , A. Emmerich 3 , H. K. Biesalski 3
  • 1Ernährungsteam des Katharinenhospitals, Klinikum Stuttgart, Stuttgart, Germany
  • 2Zentrum für Schwerbrandverletzte der Klinik für Unfallchirurgie am Marienhospital, Stuttgart, Germany
  • 3Institut für Biologische Chemie und Ernährungswissenschaft (140a), Universität Hohenheim, Stuttgart, Germany
Further Information

Publication History

Publication Date:
10 April 2007 (online)

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Abstract

In patients with extensive burns microvascular hyperpermeability occurs not only at the injured sites but also in regions distant from the injury. The mechanism of this burn oedema is still not completely understood, nor why it stops after 18-36 hours. However, there is increasing evidence that an overwhelming production of reactive oxygen and nitrogen species (ROS/RNS) plays an important role in this context. Our data document the generation of peroxynitrite (ONOO-) by detection of its footprint 3-nitrotyrosine in thermally injured human skin. The immunohistological detection reveals the location of 3-nitrotyrosine at the endothelium and further adds to the hypothesis of oxidative/nitrosative stress. A promising therapeutic approach might be high-dose antioxidant treatment as the enhanced free radical production in burn trauma is paralleled by impaired antioxidant mechanisms. The most promising results for the reduction of oedema formation and decreased early resuscitation fluid volume are known for intravenous vitamin C treatment. This paper gives a short review of the literature on this topic.

Key words

Capillary leak - oedema - iNOS - reactive oxygen/nitrogen species - vitamin C

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Correspondence

Prof. Dr. Hans Konrad Biesalski

Institute of Biological Chemistry and Nutrition (140a)

University of Hohenheim

Garbenstr. 30

70599 Stuttgart

Germany

Phone: +49/711/459 41 13

Fax: +49/711/459 38 22

Email: biesal@uni-hohenheim.de