Bipolar Switching after Carbamazepine Withdrawal

Introduction

Anticonvulsants such as the dibenzazepine derivative carbamazepine (CBZ) are effective alternatives to lithium in phase prophylaxis of bipolar disorder, particularly in the elderly [1], and in case of medical comorbidity [5]. It is well established that lithium withdrawal may precipitate recurrence of manic symptoms in bipolar patients [2]. However, rebound-affective episodes in such patients upon discontinuation of CBZ have not been recognized till to date. Here we describe a case of mania induced in a bipolar depressive patient following cessation of long-term CBZ treatment.

References

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Correspondence