Emerging Technologies in Hemostasis Diagnostics: A Report from the Australasian Society of Thrombosis and Haemostasis Emerging Technologies Group

Murray Adams; Chris Ward; Jim Thom; Alessandra Bianchi; Emma Perrin; Douglas Coghlan; Mark Smith

doi:10.1055/s-2007-971808

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2007; 33(3): 226-234
DOI: 10.1055/s-2007-971808

Emerging Technologies in Hemostasis Diagnostics: A Report from the Australasian Society of Thrombosis and Haemostasis Emerging Technologies Group

Murray Adams¹ , Chris Ward² , Jim Thom³ , Alessandra Bianchi⁴ , Emma Perrin⁵ , Douglas Coghlan⁶ , Mark Smith⁷

¹School of Human Life Sciences, University of Tasmania, Tasmania, Australia, and School of Biomedical Sciences, Curtin University of Technology, Western Australia
²Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, New South Wales, and University of Sydney, New South Wales, Australia
³Haematology Department, Royal Perth Hospital, Western Australia, Australia
⁴Department of Haematology, Concord Hospital, New South Wales, Australia
⁵Queensland Health Pathology Service, Princess Alexandra Hospital, Queensland, Australia
⁶Department of Haematology and Genetic Medicine, Flinders University, South Australia, Australia
⁷Haematology Department, Canterbury Health Laboratories, Christchurch, New Zealand

Abstract

ABSTRACT

Technology in hemostasis laboratories has evolved enormously during the last 30 years. Although many scientists and clinicians will remember the traditional tilt-tube techniques to screen for coagulation abnormalities and to monitor anticoagulant therapy, the hemostasis laboratory today uses a variety of modern technologies. These include flow cytometry, chromogenic assays, molecular typing (e.g., polymerase chain reaction), immunologic assays (e.g., enzyme-linked immunosorbent assays), functional assays of specific coagulation proteins, and platelet function analyzers. Although these advances in technology have resulted in greater capability, productivity, sensitivity, specificity, and ultimately, improvement in the clinical care of patients, controversies and limitations remain. This article highlights new and emerging technologies in hemostasis and discusses whether they have improved or are likely to improve laboratory diagnostics by specifically addressing the following: (1) Can new technologies help predict likelihood of thrombosis recurrence? (2) Has an understanding of the role of a disintegrin-like and metalloprotease with thrombospondin type 1 motifs (ADAMTS13) in microangiopathy resulted in improved diagnostic methods for this disorder? (3) Does thrombelastography allow better definition of bleeding risk than conventional hemostasis assays, especially in settings of acute hemostatic pathology?

KEYWORDS

Hemostasis - laboratory testing - thrombin generation - thrombophilia - bleeding

Full Text

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Murray AdamsPh.D.

School of Human Life Sciences, University of Tasmania

Locked Bag 1320, Tasmania 7250, Australia

Email: Murray.Adams@utas.edu.au