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Exp Clin Endocrinol Diabetes 2007; 115(8): 522-526
DOI: 10.1055/s-2007-981457
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG · Stuttgart · New York

Oxidative Stress and Enzymatic Antioxidant Status in Patients with Hypothyroidism before and after Treatment

G. Baskol 1 , H. Atmaca 2 , F. Tanrıverdi 2 , M. Baskol 3 , D. Kocer 1 , F. Bayram 2
  • 1Department of Biochemistry and Clinical Biochemistry, Erciyes University Faculty of Medicine, Kayseri, Turkey
  • 2Department of Endocrinology, Erciyes University Faculty of Medicine, Kayseri, Turkey
  • 3Department of Internal Medicine, Erciyes University Faculty of Medicine, Kayseri, Turkey
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Publication History

received 18. 01. 2007 first decision 23. 03. 2007

accepted 02. 05. 2007

Publication Date:
12 September 2007 (online)

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Abstract

The present study was designed to investigate the relationship between the serum levels of oxidant-antioxidant system (malondialdehyde (MDA) level, Paraoxonase (PON1) activity, nitric oxide (NO) level and superoxide dismutase (SOD) activity) and thyroid hormone status in hypothyroidism pre and posttreatment. The study group comprised 33 patients with primary hypothyoidism. 18 of these patients were reevaluated after euthyroid state i.e. at least 6 months of thyroxine replacement. The patients were compared with 26 normal healthy controls. Serum MDA level, PON1 activity, NO level and SOD activity were measured according to an enzymatic spectrophotometric method. MDA levels were found higher in patients with hypothyroidism before the treatment than the controls. MDA levels were also found to be decreased after the treatment in patients with hyothyroidism. However MDA were found still higher than the controls after the treatment. PON1 activity was found to be lower in patients pretreatment when compared to posttreatment hypothyroidism and controls. Posttreatment of hypothyroidism mean PON1 activity significantly increased compared to pretreatment level but it was still significantly lower than control level. NO level was higher in pretreatment hypothyroidism when compared to controls. SOD activity was not found different in patients before treatment when compared to controls. SOD activity was significantly higher in after treatment when compared to both pretreatment and control levels. In conclusion, increased ROS levels in hypothyroidism may result in a pro-oxidation environment, which in turn could result in decreased antioxidant PON1 activity, increased MDA and NO levels. As a result, lipid peroxidation may have a role in the pathogenesis of the atherosclerosis in hypothyroidism.

Key words

Lipid peroxidation - malondialdehyde - paraoxonase - hypothyroidism

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Correspondence

Asst. Prof. G. BaskolMD 

Erciyes University Faculty of Medicine

Department of Biochemistry and Clinical Biochemistry

Kayseri

Turkey

Phone: +90/352/437 49 37 ext. 23289

Fax: +90/352/437 55 65

Email: gbaskol@yahoo.com