Abstract
(-)-N -Acetylslaframine, a stable form of the indolizidine alkaloid (-)-slaframine, has been synthesised by a new strategy. Applying highly stereoselective lithiation and substitution reactions, C-2, C-3 and C-8 of the bicyclic skeleton were introduced to an l -glutamic acid derived diol dicarbamate.
Key words
indolizidines - chiral 2-amino-1-ω-alkanediols - lithiated dicarbamates - diastereoselectivity - (-)-sparteine
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