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DOI: 10.1055/s-2007-983732
Novel Synthesis and Anti-HIV-1 Activity of 2-Arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (Aryl S-DABOs)
Publication History
Publication Date:
18 June 2007 (online)
Abstract
The synthesis and the anti-HIV-1 activity of a series of 2-arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (aryl S-DABOs) are reported. These compounds were synthesized via a coupling reaction of the corresponding 6-benzyl-2-thiouracils with aryl iodides in the presence of neocuproine hydrate, copper(I) iodide, and sodium tert-butoxide. Target compounds showed moderate activity against HIV-1.
Key words
medicinal chemistry - antiviral agents - HIV - non-nucleosides - S-DABO
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References
On leave from Chemistry Department, Faculty of Education Kafr El-Sheikh branch, Tanta University, Kafr El-Sheikh, Egypt.
2A research center funded by the Danish National Research Foundation for Studies on Nucleic Acid Chemical Biology.
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