Abstract
Products containing Boc- or Tr-protected amines were caught directly out of reaction mixtures by simultaneous cleavage of the protecting group. By releasing the products with ammonia the corresponding free amines were obtained in high yields and purities. The broadly applicable method of simultaneous deprotection and purification based on ionic resin capture was applied for Grignard and Mitsunobu reactions as well as amide formations and show a high potential for multiparallel synthesis.
Key words
ion exchange - facile purification - Boc deprotection - Tr deprotection - combinatorial chemistry
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