Abstract
To date, the synthesis of l -anserine has relied on the use of naturally occurring 1-methyl-l -histidine as a precursor, however its high cost prevents its use in the large-scale synthesis of l -anserine. With this in mind, we report herein a concise and efficient synthetic strategy, employing the 160-fold less expensive, l -histidine methyl ester dihydrochloride as a starting material, to afford the title compound in an overall yield of 88%, over four reaction steps.
Key words
natural products - peptides - amino acids - coupling
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