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Synthesis 2007(18): 2779-2781
DOI: 10.1055/s-2007-983876
DOI: 10.1055/s-2007-983876
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
A Short and Efficient Synthesis of 3-[2,2,2-Trifluoroethyl]hexahydro-2H-1,4-diazepin-2-one
Further Information
Received
16 February 2007
Publication Date:
29 August 2007 (online)
Publication History
Publication Date:
29 August 2007 (online)
Abstract
A short, high yielding, five-step synthesis of the pharmaceutically interesting fluorinated heterocycle, 3-[2,2,2-trifluoroethyl]hexahydro-2H-1,4-diazepin-2-one, has been developed.
Key words
lactam - fluorine - alkylation - Michael addition - hydrogenation
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